dc.creator | Wu, Yuan Ju | es |
dc.creator | Tejero, Rocío | es |
dc.creator | Arancillo, Marife | es |
dc.creator | Vardar, Gülcin | es |
dc.creator | Korotkova, Tatiana | es |
dc.creator | Kintscher, Michael | es |
dc.creator | Tabares, Lucía | es |
dc.creator | Rosenmund, Christian | es |
dc.date.accessioned | 2023-05-17T13:33:49Z | |
dc.date.available | 2023-05-17T13:33:49Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Wu, Y.J., Tejero, R., Arancillo, M., Vardar, G., Korotkova, T., Kintscher, M.,...,Rosenmund, C. (2015). Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions. JOURNAL OF NEUROPHYSIOLOGY, 114 (4), 2404-2417. https://doi.org/10.1152/jn.00577.2015. | |
dc.identifier.issn | 0022-3077 | es |
dc.identifier.uri | https://hdl.handle.net/11441/146250 | |
dc.description.abstract | Syntaxin 1B is important for mouse postnatal survival and
proper synaptic function at the mouse neuromuscular junctions. J
Neurophysiol 114: 2404 –2417, 2015. First published July 22, 2015;
doi:10.1152/jn.00577.2015.—STX1 is a major neuronal syntaxin protein located at the plasma membrane of the neuronal tissues. Rodent
STX1 has two highly similar paralogs, STX1A and STX1B, that are
thought to be functionally redundant. Interestingly, some studies have
shown that the distribution patterns of STX1A and STX1B at the
central and peripheral nervous systems only partially overlapped,
implying that there might be differential functions between these
paralogs. In the current study, we generated an STX1B knockout
(KO) mouse line and studied the impact of STX1B removal in
neurons of several brain regions and the neuromuscular junction
(NMJ). We found that either complete removal of STX1B or selective
removal of it from forebrain excitatory neurons in mice caused
premature death. Autaptic hippocampal and striatal cultures derived
from STX1B KO mice still maintained efficient neurotransmission
compared with neurons from STX1B wild-type and heterozygous
mice. Interestingly, examining high-density cerebellar cultures revealed a decrease in the spontaneous GABAergic transmission frequency, which was most likely due to a lower number of neurons in
the STX1B KO cultures, suggesting that STX1B is essential for
neuronal survival in vitro. Moreover, our study also demonstrated that
although STX1B is dispensable for the formation of the mouse NMJ,
it is required to maintain the efficiency of neurotransmission at the
nerve-muscle synapse. | es |
dc.format | application/pdf | es |
dc.format.extent | 14 p. | es |
dc.language.iso | eng | es |
dc.publisher | AMER PHYSIOLOGICAL SOC | es |
dc.relation.ispartof | JOURNAL OF NEUROPHYSIOLOGY, 114 (4), 2404-2417. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | SNARE | es |
dc.subject | NMJ | es |
dc.subject | Neurotransmitter release | es |
dc.subject | Spontaneous release | es |
dc.subject | Evoked release | es |
dc.title | Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.relation.projectID | BFU2013-43763-P | es |
dc.relation.projectID | BES2011-048901 | es |
dc.relation.publisherversion | https://journals.physiology.org/doi/full/10.1152/jn.00577.2015 | es |
dc.identifier.doi | 10.1152/jn.00577.2015 | es |
dc.journaltitle | JOURNAL OF NEUROPHYSIOLOGY | es |
dc.publication.volumen | 114 | es |
dc.publication.issue | 4 | es |
dc.publication.initialPage | 2404 | es |
dc.publication.endPage | 2417 | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación. España | es |