dc.creator | Fernandez-Fuertes, M. | es |
dc.creator | Macías Sánchez, Juan | es |
dc.creator | Corma-Gómez, A. | es |
dc.creator | Rincón, P. | es |
dc.creator | Merchante Gutiérrez, Nicolás | es |
dc.creator | Gómez-Mateos, J. | es |
dc.creator | Pineda, J. A. | es |
dc.creator | Real, L. M. | es |
dc.date.accessioned | 2023-05-12T12:16:31Z | |
dc.date.available | 2023-05-12T12:16:31Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Fernandez-Fuertes, M., Macías Sánchez, J., Corma-Gómez, A., Rincón, P., Merchante Gutiérrez, N., Gómez-Mateos, J.,...,Real, L.M. (2020). Similar prevalence of hepatic steatosis among patients with chronic hepatitis C with and without HIV coinfection. Scientific Reports, 10 (1), 6736. https://doi.org/10.1038/s41598-020-62671-y. | |
dc.identifier.issn | 2045-2322 | es |
dc.identifier.uri | https://hdl.handle.net/11441/145941 | |
dc.description.abstract | Hepatic steatosis (HS) is frequently observed in HIV-infected patients. It is not known whether HIV infection is an independent risk factor for HS development. We aimed to analyze whether HIV coinfection was associated with a higher frequency of HS in patients with chronic hepatitis C. This was a retrospective cross-sectional study. 574 subjects with chronic hepatitis C virus (HCV) infection were included, 246 (43%) of them coinfected with HIV. All of them underwent transient elastography with controlled attenuation parameter (CAP) measurement. HS was defined as CAP ≥ 248 dB/m. 147 individuals (45%) showed HS in the HCV-monoinfected group and 100 (40.7%) in the HIV/HCV-coinfected group (p = 0.318). HS was associated with body mass index (BMI) [<25 Kg/m2 vs. ≥25 Kg/m2, 67 (23.5%) vs. 171 (62.9%); p = 0.001], with plasma HDL-cholesterol [<50 mg/dL vs. ≥50 mg/dL, 122 (48.6%) vs. 95 (37.5%), p = 0.012], with plasma triglycerides [<150 mg/dL vs. ≥150 mg/dL, 168 (40.2%) vs. 65 (52.4%); p = 0.016] and with plasma total cholesterol [<200 mg/dL vs. ≥200 mg/dL, 181 (41%) vs. 53 (52.5%); p = 0.035]. In the multivariate analysis, HS was associated with BMI [adjusted OR (AOR) = 1.264 (1.194–1.339); p = 0.001], age [AOR = 1.029 (1.001–1.058); p = 0.047] and HCV genotype 3 infection [AOR = 1.901 (1.081–2.594); p = 0.026]. HIV coinfection was not associated with HS [AOR = 1.166 (0.719–1.892); p = 0.534]. In conclusion, HIV coinfection is not related with an increased frequency of HS in HCV-infected patients. | es |
dc.format | application/pdf | es |
dc.format.extent | 7 p. | es |
dc.language.iso | eng | es |
dc.publisher | Nature Research | es |
dc.relation.ispartof | Scientific Reports, 10 (1), 6736. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Fatty liver-dise | es |
dc.subject | Controlled attenuation parameter | es |
dc.subject | Transient elastography | es |
dc.subject | Risk-factors | es |
dc.subject | Epidemiology | es |
dc.subject | Metaanalysis | es |
dc.subject | Virus | es |
dc.title | Similar prevalence of hepatic steatosis among patients with chronic hepatitis C with and without HIV coinfection | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.projectID | PI-0001/2017 | es |
dc.relation.projectID | PI15/01124 | es |
dc.relation.projectID | Programa-I3SNS | es |
dc.relation.projectID | RD12/0017/0012; RD16/0025/0040 | es |
dc.relation.projectID | B-0037 | es |
dc.relation.publisherversion | https://www.nature.com/articles/s41598-020-62671-y | es |
dc.identifier.doi | 10.1038/s41598-020-62671-y | es |
dc.journaltitle | Scientific Reports | es |
dc.publication.volumen | 10 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 6736 | es |
dc.contributor.funder | Consejeria de Salud de la Junta de Andalucia | es |
dc.contributor.funder | Fondo de Investigaciones Sanitarias | es |
dc.contributor.funder | Fondo Europeo de Desarrollo Regional (FEDER) | es |
dc.contributor.funder | Instituto de Salud Carlos III | es |
dc.contributor.funder | ISCIII-Subdireccion General de Evaluacion | es |
dc.contributor.funder | Plan Nacional R+D+I | es |
dc.contributor.funder | Servicio Andaluz de Salud de la Junta de Andalucia | es |