Artículo
Similar prevalence of hepatic steatosis among patients with chronic hepatitis C with and without HIV coinfection
Autor/es | Fernandez-Fuertes, M.
Macías Sánchez, Juan Corma-Gómez, A. Rincón, P. Merchante Gutiérrez, Nicolás Gómez-Mateos, J. Pineda, J. A. Real, L. M. |
Departamento | Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2020 |
Fecha de depósito | 2023-05-12 |
Publicado en |
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Resumen | Hepatic steatosis (HS) is frequently observed in HIV-infected patients. It is not known whether HIV infection is an independent risk factor for HS development. We aimed to analyze whether HIV coinfection was associated ... Hepatic steatosis (HS) is frequently observed in HIV-infected patients. It is not known whether HIV infection is an independent risk factor for HS development. We aimed to analyze whether HIV coinfection was associated with a higher frequency of HS in patients with chronic hepatitis C. This was a retrospective cross-sectional study. 574 subjects with chronic hepatitis C virus (HCV) infection were included, 246 (43%) of them coinfected with HIV. All of them underwent transient elastography with controlled attenuation parameter (CAP) measurement. HS was defined as CAP ≥ 248 dB/m. 147 individuals (45%) showed HS in the HCV-monoinfected group and 100 (40.7%) in the HIV/HCV-coinfected group (p = 0.318). HS was associated with body mass index (BMI) [<25 Kg/m2 vs. ≥25 Kg/m2, 67 (23.5%) vs. 171 (62.9%); p = 0.001], with plasma HDL-cholesterol [<50 mg/dL vs. ≥50 mg/dL, 122 (48.6%) vs. 95 (37.5%), p = 0.012], with plasma triglycerides [<150 mg/dL vs. ≥150 mg/dL, 168 (40.2%) vs. 65 (52.4%); p = 0.016] and with plasma total cholesterol [<200 mg/dL vs. ≥200 mg/dL, 181 (41%) vs. 53 (52.5%); p = 0.035]. In the multivariate analysis, HS was associated with BMI [adjusted OR (AOR) = 1.264 (1.194–1.339); p = 0.001], age [AOR = 1.029 (1.001–1.058); p = 0.047] and HCV genotype 3 infection [AOR = 1.901 (1.081–2.594); p = 0.026]. HIV coinfection was not associated with HS [AOR = 1.166 (0.719–1.892); p = 0.534]. In conclusion, HIV coinfection is not related with an increased frequency of HS in HCV-infected patients. |
Agencias financiadoras | Consejeria de Salud de la Junta de Andalucia Fondo de Investigaciones Sanitarias Fondo Europeo de Desarrollo Regional (FEDER) Instituto de Salud Carlos III ISCIII-Subdireccion General de Evaluacion Plan Nacional R+D+I Servicio Andaluz de Salud de la Junta de Andalucia |
Identificador del proyecto | PI-0001/2017
PI15/01124 Programa-I3SNS RD12/0017/0012; RD16/0025/0040 B-0037 |
Cita | Fernandez-Fuertes, M., Macías Sánchez, J., Corma-Gómez, A., Rincón, P., Merchante Gutiérrez, N., Gómez-Mateos, J.,...,Real, L.M. (2020). Similar prevalence of hepatic steatosis among patients with chronic hepatitis C with and without HIV coinfection. Scientific Reports, 10 (1), 6736. https://doi.org/10.1038/s41598-020-62671-y. |
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