dc.creator | Garrido-Torres, Nathalia | es |
dc.creator | Cerrillos, Lucas | es |
dc.creator | García Cerro, Susana | es |
dc.creator | Pérez Gómez, Alberto | es |
dc.creator | Canal-Rivero, Manuel | es |
dc.creator | Felipe, Beatriz de | es |
dc.creator | López Díaz, Álvaro | es |
dc.creator | Romero García, Rafael | es |
dc.creator | Olbrich, Peter | es |
dc.creator | Cisneros, José Miguel | es |
dc.creator | Crespo Facorro, Benedicto | es |
dc.creator | Ruiz Veguilla, Miguel | es |
dc.date.accessioned | 2023-03-31T18:41:23Z | |
dc.date.available | 2023-03-31T18:41:23Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Garrido-Torres, N., Cerrillos, L., García Cerro, S., Pérez Gómez, A., Canal-Rivero, M., de Felipe, B.,...,Ruiz Veguilla, M. (2022). Examining the immune signatures of SARS-CoV-2 infection in pregnancy and the impact on neurodevelopment: protocol of the SIGNATURE longitudinal study. FRONTIERS IN PEDIATRICS, 10, 899445. https://doi.org/10.3389/fped.2022.899445. | |
dc.identifier.issn | 2296-2360 | es |
dc.identifier.uri | https://hdl.handle.net/11441/143863 | |
dc.description.abstract | The COVID-19 pandemic represents a valuable opportunity to carry out cohort
studies that allow us to advance our knowledge on pathophysiological
mechanisms of neuropsychiatric diseases. One of these opportunities is the
study of the relationships between inflammation, brain development and an
increased risk of suffering neuropsychiatric disorders. Based on the
hypothesis that neuroinflammation during early stages of life is associated
with neurodevelopmental disorders and confers a greater risk of developing
neuropsychiatric disorders, we propose a cohort study of SARS-CoV-2-
infected pregnant women and their newborns. The main objective of
SIGNATURE project is to explore how the presence of prenatal SARS-CoV-2
infection and other non-infectious stressors generates an abnormal
inflammatory activity in the newborn. The cohort of women during the
COVID-19 pandemic will be psychological and biological monitored during
their pregnancy, delivery, childbirth and postpartum. The biological
information of the umbilical cord (foetus blood) and peripheral blood from
the mother will be obtained after childbirth. These samples and the clinical
characterisation of the cohort of mothers and newborns, are tremendously
valuable at this time. This is a protocol report and no analyses have been
conducted yet, being currently at, our study is in the recruitment process
step. At the time of this publication, we have identified 1,060 SARS-CoV-2
infected mothers and all have already given birth. From the total of identified
mothers, we have recruited 537 SARS-COV-2 infected women and all of
them have completed the mental health assessment during pregnancy. We
have collected biological samples from 119 mothers and babies. Additionally,
we have recruited 390 non-infected pregnant women. | es |
dc.format | application/pdf | es |
dc.format.extent | 12 p. | es |
dc.language.iso | eng | es |
dc.publisher | FRONTIERS MEDIA SA | es |
dc.relation.ispartof | FRONTIERS IN PEDIATRICS, 10, 899445. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Pregnancy | es |
dc.subject | Neurodevelomental disorders | es |
dc.subject | COVI-19 pandemic | es |
dc.subject | SARS-CoV-2 | es |
dc.subject | Autism (ASD) | es |
dc.subject | Maternal mental health | es |
dc.title | Examining the immune signatures of SARS-CoV-2 infection in pregnancy and the impact on neurodevelopment: protocol of the SIGNATURE longitudinal study | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Psiquiatría | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacología, Pediatría y Radiología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fped.2022.899445/full | es |
dc.identifier.doi | 10.3389/fped.2022.899445 | es |
dc.journaltitle | FRONTIERS IN PEDIATRICS | es |
dc.publication.volumen | 10 | es |
dc.publication.initialPage | 899445 | es |