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dc.creatorHirzel, Cedrices
dc.creatorChruscinski, Andrzejes
dc.creatorFerreira, Victor H.es
dc.creatorL’Huillier, Arnaud G.es
dc.creatorNatori, Yochiroes
dc.creatorHoon Han, Sanges
dc.creatorCordero Matia, María Elisaes
dc.creatorHumar, Atules
dc.creatorKumar, Deepalies
dc.date.accessioned2022-12-30T09:52:12Z
dc.date.available2022-12-30T09:52:12Z
dc.date.issued2021-08
dc.identifier.citationHirzel, C., Chruscinski, A., Ferreira, V.H., L’Huillier, A.G., Natori, Y., Hoon Han, S.,...,Kumar, D. (2021). Natural influenza infection produces a greater diversity of humoral responses than vaccination in immunosuppressed transplant recipients. American Journal of Transplantation, 21 (8), 2709-2718. https://doi.org/10.1111/ajt.16503.
dc.identifier.issn1600-6135;1600-6143es
dc.identifier.urihttps://hdl.handle.net/11441/140866
dc.description.abstractThe humoral immune response to influenza virus infection is complex and may be different compared to the antibody response elicited by vaccination. We analyzed the breadth of IgG and IgA responses in solid organ transplant (SOT) recipients to a diverse collection of 86 influenza antigens elicited by natural influenza A virus (IAV) infection or by vaccination. Antibody levels were quantified using a custom antigen microarray. A total of 120 patients were included: 80 IAV infected (40 A/H1N1 and 40 A/H3N2) and 40 vaccinated. Based on hierarchical clustering analysis, infection with either H1N1 or H3N2 virus showed a more diverse antibody response compared to vaccination. Similarly, H1N1-infected individuals showed a significant IgG response to 27.9% of array antigens and H3N2-infected patients to 43.0% of antigens, whereas vaccination elicited a less broad immune response (7.0% of antigens). Immune responses were not exclusively targeting influenza hemagglutinin (HA) proteins but were also directed against conserved influenza antigens. Serum IgA responses followed a similar profile. This study provides novel data on the breadth of antibody responses to influenza. We also found that the diversity of response is greater in influenza-infected rather than vaccinated patients, providing a potential mechanistic rationale for suboptimal vaccine efficacy in this population.es
dc.formatapplication/pdfes
dc.format.extent10 p.es
dc.language.isoenges
dc.publisherWiley-Blackwelles
dc.relation.ispartofAmerican Journal of Transplantation, 21 (8), 2709-2718.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectcomplicationes
dc.subjectinfectiouses
dc.subjectinfection and infectious agents - virales
dc.subjectinfluenzaes
dc.subjectinfectious diseasees
dc.subjecttranslational research / sciencees
dc.subjectVaccinees
dc.titleNatural influenza infection produces a greater diversity of humoral responses than vaccination in immunosuppressed transplant recipientses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Medicinaes
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1600613522086701?via%3Dihubes
dc.identifier.doi10.1111/ajt.16503es
dc.journaltitleAmerican Journal of Transplantationes
dc.publication.volumen21es
dc.publication.issue8es
dc.publication.initialPage2709es
dc.publication.endPage2718es

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