Article
Natural influenza infection produces a greater diversity of humoral responses than vaccination in immunosuppressed transplant recipients
Author/s | Hirzel, Cedric
Chruscinski, Andrzej Ferreira, Victor H. L’Huillier, Arnaud G. Natori, Yochiro Hoon Han, Sang Cordero Matia, María Elisa Humar, Atul Kumar, Deepali |
Department | Universidad de Sevilla. Departamento de Medicina |
Publication Date | 2021-08 |
Deposit Date | 2022-12-30 |
Published in |
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Abstract | The humoral immune response to influenza virus infection is complex and may be different compared to the antibody response elicited by vaccination. We analyzed the breadth of IgG and IgA responses in solid organ transplant ... The humoral immune response to influenza virus infection is complex and may be different compared to the antibody response elicited by vaccination. We analyzed the breadth of IgG and IgA responses in solid organ transplant (SOT) recipients to a diverse collection of 86 influenza antigens elicited by natural influenza A virus (IAV) infection or by vaccination. Antibody levels were quantified using a custom antigen microarray. A total of 120 patients were included: 80 IAV infected (40 A/H1N1 and 40 A/H3N2) and 40 vaccinated. Based on hierarchical clustering analysis, infection with either H1N1 or H3N2 virus showed a more diverse antibody response compared to vaccination. Similarly, H1N1-infected individuals showed a significant IgG response to 27.9% of array antigens and H3N2-infected patients to 43.0% of antigens, whereas vaccination elicited a less broad immune response (7.0% of antigens). Immune responses were not exclusively targeting influenza hemagglutinin (HA) proteins but were also directed against conserved influenza antigens. Serum IgA responses followed a similar profile. This study provides novel data on the breadth of antibody responses to influenza. We also found that the diversity of response is greater in influenza-infected rather than vaccinated patients, providing a potential mechanistic rationale for suboptimal vaccine efficacy in this population. |
Citation | Hirzel, C., Chruscinski, A., Ferreira, V.H., L’Huillier, A.G., Natori, Y., Hoon Han, S.,...,Kumar, D. (2021). Natural influenza infection produces a greater diversity of humoral responses than vaccination in immunosuppressed transplant recipients. American Journal of Transplantation, 21 (8), 2709-2718. https://doi.org/10.1111/ajt.16503. |
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