dc.creator | Manzanares, Darío | es |
dc.creator | Araya Durán, Ingrid | es |
dc.creator | Gallego Yerga, Laura | es |
dc.creator | Játiva, Pablo | es |
dc.creator | Márquez Miranda, Valeria | es |
dc.creator | Canan, Jonathan | es |
dc.creator | Jiménez Blanco, José Luis | es |
dc.creator | Ortiz Mellet, Carmen | es |
dc.creator | González Nilo, Fernando Danilo | es |
dc.creator | García Fernández, José Manuel | es |
dc.creator | Ceña, Valentín | es |
dc.date.accessioned | 2022-12-20T17:43:27Z | |
dc.date.available | 2022-12-20T17:43:27Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Manzanares, D., Araya Durán, I., Gallego Yerga, L., Játiva, P., Márquez Miranda, V., Canan, J.,...,Ceña, V. (2017). Molecular Determinants for Cyclo-oligosaccharide-based Nanoparticle-mediated Effective siRNA Transfection. Nanomedicine, 12 (13), 1607-1621. https://doi.org/10.2217/nnm-2017-0123. | |
dc.identifier.issn | 1743-5889 | es |
dc.identifier.issn | 1748-6963 | es |
dc.identifier.uri | https://hdl.handle.net/11441/140690 | |
dc.description.abstract | Aim: To study the structural requirements that a cyclooligosaccharide-based nanoparticle must fulfill to be an efficient siRNA transfection vector. Materials & methods: siRNA protection from degradation by RNAses, transfection efficiency and the thermodynamic parameters of the nanoparticle/siRNA interactions were studied on pairs of amphiphilic molecules using biochemical techniques and molecular dynamics. Results: The lower the siRNA solvent accessible surface area in the presence of the nanoparticle, higher the protection from RNAse-mediated degradation in the corresponding nanocomplex; a moderate nanoparticle/siRNA binding energy value further facilitates reversible complexation and binding to the target cellular mRNA. Conclusion: The use, in advance, of these parameters will provide a useful indication of the potential of a molecular nanoparticle as siRNA transfecting vector. | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad BFU2014-59009-P, SAF2016-76083-R, CTQ2015-64425-C2-1-R | es |
dc.description.sponsorship | Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo 214RT0482 | es |
dc.description.sponsorship | Corporación de Fomento de la Producción FCR-CSB 09CEII-6991 | es |
dc.description.sponsorship | Junta de Andalucía FQM2012-1467 | es |
dc.format | application/pdf | es |
dc.format.extent | 56 p. | es |
dc.language.iso | eng | es |
dc.publisher | Future Medicine Ltd. | es |
dc.relation.ispartof | Nanomedicine, 12 (13), 1607-1621. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Endosomal escape | es |
dc.subject | Molecular modeling | es |
dc.subject | Molecular nanoparticle | es |
dc.subject | Protection from RNAses | es |
dc.subject | Protein knock down | es |
dc.subject | siRNA transfection | es |
dc.title | Molecular Determinants for Cyclo-oligosaccharide-based Nanoparticle-mediated Effective siRNA Transfection | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química orgánica | es |
dc.relation.projectID | BFU2014-59009-P | es |
dc.relation.projectID | SAF2016-76083-R | es |
dc.relation.projectID | CTQ2015-64425-C2-1-R | es |
dc.relation.projectID | 214RT0482 | es |
dc.relation.projectID | FCR-CSB 09CEII-6991 | es |
dc.relation.projectID | FQM2012-1467 | es |
dc.relation.publisherversion | https://doi.org/10.2217/nnm-2017-0123 | es |
dc.identifier.doi | 10.2217/nnm-2017-0123 | es |
dc.journaltitle | Nanomedicine | es |
dc.publication.volumen | 12 | es |
dc.publication.issue | 13 | es |
dc.publication.initialPage | 1607 | es |
dc.publication.endPage | 1621 | es |
dc.contributor.funder | Ministerio de Economía y Competitividad (MINECO). España | es |
dc.contributor.funder | Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo (CYTED) | es |
dc.contributor.funder | Corporación de Fomento de la Producción (CORFO). Chile | es |
dc.contributor.funder | Junta de Andalucía | es |