dc.creator | González Calvo, Inés | es |
dc.creator | Cizeron, Melissa | es |
dc.creator | Bessereau, Jean-Louis | es |
dc.creator | Selimi, Fekrije | es |
dc.date.accessioned | 2022-12-16T14:14:18Z | |
dc.date.available | 2022-12-16T14:14:18Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | González Calvo, I., Cizeron, M., Bessereau, J. y Selimi, F. (2022). Synapse Formation and Function Across Species: Ancient Roles for CCP, CUB, and TSP-1 Structural Domains. Frontiers in Neuroscience, 16, 866444. https://doi.org/10.3389/fnins.2022.866444. | |
dc.identifier.issn | 1662-453X | es |
dc.identifier.uri | https://hdl.handle.net/11441/140580 | |
dc.description.abstract | The appearance of synapses was a crucial step in the creation of the variety of
nervous systems that are found in the animal kingdom. With increased complexity of
the organisms came a greater number of synaptic proteins. In this review we describe
synaptic proteins that contain the structural domains CUB, CCP, or TSP-1. These
domains are found in invertebrates and vertebrates, and CUB and CCP domains
were initially described in proteins belonging to the complement system of innate
immunity. Interestingly, they are found in synapses of the nematode C. elegans, which
does not have a complement system, suggesting an ancient function. Comparison of
the roles of CUB-, CCP-, and TSP-1 containing synaptic proteins in various species
shows that in more complex nervous systems, these structural domains are combined
with other domains and that there is partial conservation of their function. These
three domains are thus basic building blocks of the synaptic architecture. Further
studies of structural domains characteristic of synaptic proteins in invertebrates such as
C. elegans and comparison of their role in mammals will help identify other conserved
synaptic molecular building blocks. Furthermore, this type of functional comparison
across species will also identify structural domains added during evolution in correlation
with increased complexity, shedding light on mechanisms underlying cognition and
brain diseases. | es |
dc.format | application/pdf | es |
dc.format.extent | 15 p. | es |
dc.language.iso | eng | es |
dc.publisher | Frontiers Media S.A. | es |
dc.relation.ispartof | Frontiers in Neuroscience, 16, 866444. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Synapse | es |
dc.subject | Molecular conservation | es |
dc.subject | CCP | es |
dc.subject | CUB | es |
dc.subject | TSP-1 | es |
dc.subject | Invertebrates | es |
dc.subject | Vertebrates | es |
dc.title | Synapse Formation and Function Across Species: Ancient Roles for CCP, CUB, and TSP-1 Structural Domains | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fnins.2022.866444/full | es |
dc.identifier.doi | 10.3389/fnins.2022.866444 | es |
dc.journaltitle | Frontiers in Neuroscience | es |
dc.publication.volumen | 16 | es |
dc.publication.initialPage | 866444 | es |