dc.creator | Díez, Cristina | es |
dc.creator | Romero-Raposo, Jorge del | es |
dc.creator | Micán, Rafael | es |
dc.creator | López, Juan C. | es |
dc.creator | Blanco, José R. | es |
dc.creator | Calzado, Sonia | es |
dc.creator | López Cortés, Luis Fernando | es |
dc.creator | González-Serna Martín, Manuel Alejandro | es |
dc.creator | Macías Sánchez, Juan | es |
dc.creator | Merchante Gutiérrez, Nicolás | es |
dc.date.accessioned | 2022-12-01T14:23:42Z | |
dc.date.available | 2022-12-01T14:23:42Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Díez, C., Romero-Raposo, J.d., Micán, R., López, J.C., Blanco, J.R., Calzado, S.,...,Merchante Gutiérrez, N. (2021). COVID-19 in hospitalized HIV-positive and HIV-negative patients: a matched study. HIV Medicine, 22 (9), 867-876. https://doi.org/10.1111/hiv.13145. | |
dc.identifier.issn | 1464-2662 | es |
dc.identifier.uri | https://hdl.handle.net/11441/140030 | |
dc.description.abstract | Objectives: We compared the characteristics and clinical outcomes of hospitalized
individuals with COVID-19
with [people with HIV (PWH)] and without (non-PWH)
HIV co-infection
in Spain during the first wave of the pandemic. Methods: This was a retrospective matched cohort study. People with HIV were identified
by reviewing clinical records and laboratory registries of 10 922 patients in active-follow-
up
within the Spanish HIV Research Network (CoRIS) up to 30 June 2020. Each
hospitalized PWH was matched with five non-PWH
of the same age and sex randomly
selected from COVID-19@
Spain, a multicentre cohort of 4035 patients hospitalized
with confirmed COVID-19.
The main outcome was all-cause
in-hospital
mortality.
Results: Forty-five
PWH with PCR-confirmed
COVID-19
were identified in CoRIS,
21 of whom were hospitalized. A total of 105 age/sex-matched
controls were selected
from the COVID-19@
Spain cohort. The median age in both groups was 53 (Q1–Q3,
46–56)
years, and 90.5% were men. In PWH, 19.1% were injecting drug users, 95.2%
were on antiretroviral therapy, 94.4% had HIV-RNA
< 50 copies/mL, and the median
(Q1–Q3)
CD4 count was 595 (349–798)
cells/μL. No statistically significant differences
were found between PWH and non-PWH
in number of comorbidities, presenting
signs and symptoms, laboratory parameters, radiology findings and severity
scores on admission. Corticosteroids were administered to 33.3% and 27.4% of PWH
and non-PWH,
respectively (P = 0.580). Deaths during admission were documented
in two (9.5%) PWH and 12 (11.4%) non-PWH
(P = 0.800).
Conclusions: Our findings suggest that well-controlled
HIV infection does not modify
the clinical presentation or worsen clinical outcomes of COVID-19
hospitalization. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 p. | es |
dc.language.iso | eng | es |
dc.publisher | Wiley | es |
dc.relation.ispartof | HIV Medicine, 22 (9), 867-876. | |
dc.rights | Atribución-NoComercial 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject | Coronavirus | es |
dc.subject | COVID-19 | es |
dc.subject | HIV | es |
dc.subject | SARS-CoV- 2 | es |
dc.title | COVID-19 in hospitalized HIV-positive and HIV-negative patients: a matched study | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/10.1111/hiv.13145 | es |
dc.identifier.doi | 10.1111/hiv.13145 | es |
dc.journaltitle | HIV Medicine | es |
dc.publication.volumen | 22 | es |
dc.publication.issue | 9 | es |
dc.publication.initialPage | 867 | es |
dc.publication.endPage | 876 | es |
dc.contributor.funder | Instituto de Salud Carlos III | es |