Artículo
COVID-19 in hospitalized HIV-positive and HIV-negative patients: a matched study
Autor/es | Díez, Cristina
Romero-Raposo, Jorge del Micán, Rafael López, Juan C. Blanco, José R. Calzado, Sonia López Cortés, Luis Fernando González-Serna Martín, Manuel Alejandro Macías Sánchez, Juan Merchante Gutiérrez, Nicolás |
Departamento | Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2021 |
Fecha de depósito | 2022-12-01 |
Publicado en |
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Resumen | Objectives: We compared the characteristics and clinical outcomes of hospitalized
individuals with COVID-19
with [people with HIV (PWH)] and without (non-PWH)
HIV co-infection
in Spain during the first wave of the ... Objectives: We compared the characteristics and clinical outcomes of hospitalized individuals with COVID-19 with [people with HIV (PWH)] and without (non-PWH) HIV co-infection in Spain during the first wave of the pandemic. Methods: This was a retrospective matched cohort study. People with HIV were identified by reviewing clinical records and laboratory registries of 10 922 patients in active-follow- up within the Spanish HIV Research Network (CoRIS) up to 30 June 2020. Each hospitalized PWH was matched with five non-PWH of the same age and sex randomly selected from COVID-19@ Spain, a multicentre cohort of 4035 patients hospitalized with confirmed COVID-19. The main outcome was all-cause in-hospital mortality. Results: Forty-five PWH with PCR-confirmed COVID-19 were identified in CoRIS, 21 of whom were hospitalized. A total of 105 age/sex-matched controls were selected from the COVID-19@ Spain cohort. The median age in both groups was 53 (Q1–Q3, 46–56) years, and 90.5% were men. In PWH, 19.1% were injecting drug users, 95.2% were on antiretroviral therapy, 94.4% had HIV-RNA < 50 copies/mL, and the median (Q1–Q3) CD4 count was 595 (349–798) cells/μL. No statistically significant differences were found between PWH and non-PWH in number of comorbidities, presenting signs and symptoms, laboratory parameters, radiology findings and severity scores on admission. Corticosteroids were administered to 33.3% and 27.4% of PWH and non-PWH, respectively (P = 0.580). Deaths during admission were documented in two (9.5%) PWH and 12 (11.4%) non-PWH (P = 0.800). Conclusions: Our findings suggest that well-controlled HIV infection does not modify the clinical presentation or worsen clinical outcomes of COVID-19 hospitalization. |
Agencias financiadoras | Instituto de Salud Carlos III |
Cita | Díez, C., Romero-Raposo, J.d., Micán, R., López, J.C., Blanco, J.R., Calzado, S.,...,Merchante Gutiérrez, N. (2021). COVID-19 in hospitalized HIV-positive and HIV-negative patients: a matched study. HIV Medicine, 22 (9), 867-876. https://doi.org/10.1111/hiv.13145. |
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