dc.creator | Matador Martínez, Esteban | es |
dc.creator | Iglesias Sigüenza, Francisco Javier | es |
dc.creator | Monge Fernández, David | es |
dc.creator | Merino, Pedro | es |
dc.creator | Fernández Fernández, Rosario Fátima | es |
dc.creator | Lassaletta, J. M. | es |
dc.date.accessioned | 2022-11-28T14:08:59Z | |
dc.date.available | 2022-11-28T14:08:59Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Matador Martínez, E., Iglesias Sigüenza, F.J., Monge Fernández, D., Merino, P., Fernández Fernández, R.F. y Lassaletta, J.M. (2021). Enantio- and Diastereoselective Nucleophilic Addition of N-tert-Butylhydrazones to Isoquinolinium Ions through Anion-Binding Catalysis. Angewandte Chemie - International Edition, 60 (10), 5096-5101. https://doi.org/10.1002/anie.202012861. | |
dc.identifier.issn | 1433-7851 | es |
dc.identifier.issn | 1521-3773 | es |
dc.identifier.uri | https://hdl.handle.net/11441/139856 | |
dc.description.abstract | A highly enantio- and diastereoselective thiourea-catalyzed dearomatization of isoquinolines employing N-tert-butylhydrazones as neutral α-azo carbanions and masked acyl anion equivalents has been developed. Experimental and computational data supports the generation of highly ordered complexes wherein the chloride behaves as a template for the catalyst, the hydrazone reagent, and the isoquinolinium cation, providing excellent stereocontrol in the formation of two contiguous stereogenic centers. The ensuing selective and high-yielding transformations provide appealing dihydroisoquinoline derivatives. | es |
dc.description.sponsorship | Ministerio de Ciencia, Innovación y Universidades PID2019-106358GB-C21, PID2019-106358GB-C22, PID2019-104090RB-100 | es |
dc.description.sponsorship | Gobierno de Aragón, E34_20R | es |
dc.description.sponsorship | Junta de Andalucía P18-FR-3531, P18-FR-644, US-1262867 | es |
dc.format | application/pdf | es |
dc.format.extent | 7 p. | es |
dc.language.iso | eng | es |
dc.publisher | Wiley-Blackwell | es |
dc.relation.ispartof | Angewandte Chemie - International Edition, 60 (10), 5096-5101. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Acylation | es |
dc.subject | Asymmetric catalysis | es |
dc.subject | Dearomatization | es |
dc.subject | Hydrazones | es |
dc.subject | Organocatalysis | es |
dc.title | Enantio- and Diastereoselective Nucleophilic Addition of N-tert-Butylhydrazones to Isoquinolinium Ions through Anion-Binding Catalysis | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química orgánica | es |
dc.relation.projectID | PID2019-106358GB-C21 | es |
dc.relation.projectID | PID2019-106358GB-C22 | es |
dc.relation.projectID | PID2019-104090RB-100 | es |
dc.relation.projectID | E34_20R | es |
dc.relation.projectID | P18-FR-3531 | es |
dc.relation.projectID | P18-FR-644 | es |
dc.relation.projectID | US-1262867 | es |
dc.relation.publisherversion | https://dx.doi.org/10.1002/anie.202012861 | es |
dc.identifier.doi | 10.1002/anie.202012861 | es |
dc.journaltitle | Angewandte Chemie - International Edition | es |
dc.publication.volumen | 60 | es |
dc.publication.issue | 10 | es |
dc.publication.initialPage | 5096 | es |
dc.publication.endPage | 5101 | es |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (MICINN). España | es |
dc.contributor.funder | Gobierno de Aragón | es |
dc.contributor.funder | Junta de Andalucía | es |
dc.description.awardwinning | Premio Anual Publicación Científica Destacada de la US. Facultad de Química | |