dc.creator | Torres-Torrelo, Hortensia | es |
dc.creator | Ortega Sáenz, Patricia | es |
dc.creator | López Barneo, José | es |
dc.date.accessioned | 2022-11-24T14:10:31Z | |
dc.date.available | 2022-11-24T14:10:31Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Torres-Torrelo, H., Ortega Sáenz, P. y López Barneo, J. (2021). Lactate sensing mechanisms in arterial chemoreceptor cells. Nature Communications, 12 (1), 4166. https://doi.org/10.1038/s41467-021-24444-7. | |
dc.identifier.issn | 2041-1723 | es |
dc.identifier.uri | https://hdl.handle.net/11441/139753 | |
dc.description.abstract | Classically considered a by-product of anaerobic metabolism, lactate is now viewed as a
fundamental fuel for oxidative phosphorylation in mitochondria, and preferred over glucose
by many tissues. Lactate is also a signaling molecule of increasing medical relevance. Lactate
levels in the blood can increase in both normal and pathophysiological conditions (e.g.,
hypoxia, physical exercise, or sepsis), however the manner by which these changes are
sensed and induce adaptive responses is unknown. Here we show that the carotid body (CB)
is essential for lactate homeostasis and that CB glomus cells, the main oxygen sensing
arterial chemoreceptors, are also lactate sensors. Lactate is transported into glomus cells,
leading to a rapid increase in the cytosolic NADH/NAD+ ratio. This in turn activates
membrane cation channels, leading to cell depolarization, action potential firing, and Ca2+
influx. Lactate also decreases intracellular pH and increases mitochondrial reactive oxygen
species production, which further activates glomus cells. Lactate and hypoxia, although
sensed by separate mechanisms, share the same final signaling pathway and jointly activate
glomus cells to potentiate compensatory cardiorespiratory reflexes. | es |
dc.format | application/pdf | es |
dc.format.extent | 13 | es |
dc.language.iso | eng | es |
dc.relation.ispartof | Nature Communications, 12 (1), 4166. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Lactate sensing mechanisms in arterial chemoreceptor cells | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.relation.projectID | SAF2016-74990-R | es |
dc.relation.publisherversion | https://www.nature.com/articles/s41467-021-24444-7 | es |
dc.identifier.doi | 10.1038/s41467-021-24444-7 | es |
dc.journaltitle | Nature Communications | es |
dc.publication.volumen | 12 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 4166 | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación | es |