Article
Association between the Mediterranean diet and metabolic syndrome with serum levels of miRNA in morbid obesity
Author/s | Fontalba-Romero, M. I.
López Enriquez, Soledad Lago-Sampedro, A. García-Escobar, E. Pastori, R. L. Domínguez-Bendala, J. García-Serrano, S. |
Department | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología |
Publication Date | 2021-01-29 |
Deposit Date | 2022-11-16 |
Published in |
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Abstract | Background: The Mediterranean diet (MD) could be involved in the regulation of different
miRNAs related to metabolic syndrome (MS). Methods: We analyzed the serum level of mir-let7a-5p,
mir-21, mir-590, mir-107 and mir-192 ... Background: The Mediterranean diet (MD) could be involved in the regulation of different miRNAs related to metabolic syndrome (MS). Methods: We analyzed the serum level of mir-let7a-5p, mir-21, mir-590, mir-107 and mir-192 in patients with morbid obesity and its association with the MD and MS. Results: There is an association between the adherence to MD and higher serum levels of mir-590. Mir-590 was lower in those patients who consumed >2 commercial pastries/week. Mir-let7a was lower in those who consumed ≥1 sweetened drinks, in those who consumed ≥3 pieces of fruit/day and in those who consumed less red than white meat. A lower mir-590 and mir-let7a, and a higher mir-192 level, were found in patients who met the high-density lipoprotein cholesterol (HDL) criterion of MS. A higher mir-192 was found in those patients who met the triglyceride criterion of MS and in those with type 2 diabetes (T2DM). Conclusions: There is an association between specific serum levels of miRNAs and the amount and kind of food intake related to MD. Mir-590 was positively associated with a healthy metabolic profile and type of diet, while mir-192 was positively associated with a worse metabolic profile. These associations could be suggestive of a possible modulation of these miRNAs by food. |
Funding agencies | Consejeria de Salud de la Junta de Andalucia (Spain) Instituto de Salud Carlos III (España) |
Project ID. | PI-0337-2016
PI18/01165 |
Citation | Fontalba-Romero, M.I., López Enriquez, S., Lago-Sampedro, A., García-Escobar, E., Pastori, R.L., Domínguez-Bendala, J. y García-Serrano, S. (2021). Association between the Mediterranean diet and metabolic syndrome with serum levels of miRNA in morbid obesity. Nutrients, 13 (2), 436. https://doi.org/10.3390/nu13020436. |
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