Mostrar el registro sencillo del ítem

Artículo

dc.creatorCarbajo Gordillo, Ana Isabeles
dc.creatorLópez Fernández, Josées
dc.creatorBenito, Juan Manueles
dc.creatorJiménez Blanco, José Luises
dc.creatorSantana Armas, María Luisaes
dc.creatorMarcelo, Gemaes
dc.creatorOrtiz Mellet, Carmenes
dc.creatorGarcía Fernández, José Manueles
dc.date.accessioned2022-11-14T12:10:03Z
dc.date.available2022-11-14T12:10:03Z
dc.date.issued2022
dc.identifier.citationCarbajo Gordillo, A.I., López Fernández, J., Benito, J.M., Jiménez Blanco, J.L., Santana Armas, M.L., Marcelo, G.,...,García Fernández, J.M. (2022). Enhanced Gene Delivery Triggered by Dual pH/Redox Responsive Host-Guest Dimerization of Cyclooligosaccharide Star Polycations. Macromolecular Rapid Communications, 43 (11), 2200145. https://doi.org/10.1002/marc.202200145.
dc.identifier.issn1022-1336es
dc.identifier.issn1521-3927es
dc.identifier.urihttps://hdl.handle.net/11441/139392
dc.description.abstractA robust strategy is reported to build perfectly monodisperse star polycationscombining a trehalose-based cyclooligosaccharide (cyclotrehalan, CT) centralcore onto which oligoethyleneimine radial arms are installed. Thearchitectural perfection of the compounds is demonstrated by a variety ofphysicochemical techniques, including NMR, MS, DLS, TEM, and GPC. Key tothe strategy is the possibility of customizing the cavity size of the macrocyclicplatform to enable/prevent the inclusion of adamantane motifs. Theseproperties can be taken into advantage to implement sequential levels ofstimuli responsiveness by combining computational design, precisionchemistry and programmed host-guest interactions. Specifically, it is shownthat supramolecular dimers implying a trimeric CT-tetraethyleneimine starpolycation and purposely designed bis-adamantane guests are preorganizedto efficiently complex plasmid DNA (pDNA) into transfection-competentnanocomplexes. The stability of the dimer species is responsive to theprotonation state of the cationic clusters, resulting in dissociation at acidicpH. This process facilitates endosomal escape, but reassembling can takeplace in the cytosol then handicapping pDNA nuclear import. By equippingthe ditopic guest with a redox-sensitive disulfide group, recapturingphenomena are prevented, resulting in drastically improved transfectionefficiencies both in vivo and in vitro.es
dc.description.sponsorshipMinisterio de Ciencia e Innovación y Agencia Estatal de Investigación, de España-MCIN/AEI/10.13039/501100011033es
dc.description.sponsorshipFondo Europeo de Desarrollo Regional de la Unión Europea-RTI2018-097609-B-C21, RTI2018-097609-B-C22, PID2019-105858RB-I00 y PID2020-118384GB-I00es
dc.description.sponsorshipJunta de Andalucía-P20_00166es
dc.formatapplication/pdfes
dc.format.extent8 p.es
dc.language.isoenges
dc.publisherWileyes
dc.relation.ispartofMacromolecular Rapid Communications, 43 (11), 2200145.
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleEnhanced Gene Delivery Triggered by Dual pH/Redox Responsive Host-Guest Dimerization of Cyclooligosaccharide Star Polycationses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Química orgánicaes
dc.relation.projectIDMCIN/AEI/10.13039/501100011033es
dc.relation.projectIDRTI2018-097609-B-C21es
dc.relation.projectIDRTI2018-097609-B-C22es
dc.relation.projectIDPID2019-105858RB-I00es
dc.relation.projectIDPID2020-118384GB-I00es
dc.relation.projectIDP20_00166es
dc.relation.publisherversionhttps://doi.org/10.1002/marc.202200145es
dc.identifier.doi10.1002/marc.202200145es
dc.journaltitleMacromolecular Rapid Communicationses
dc.publication.volumen43es
dc.publication.issue11es
dc.publication.initialPage2200145es
dc.contributor.funderMinisterio de Ciencia e Innovación (MICIN). Españaes
dc.contributor.funderAgencia Estatal de Investigación. Españaes
dc.contributor.funderEuropean Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER)es
dc.contributor.funderJunta de Andalucíaes

FicherosTamañoFormatoVerDescripción
Macromolecular Rapid Communications ...4.026MbIcon   [PDF] Ver/Abrir  

Este registro aparece en las siguientes colecciones

Mostrar el registro sencillo del ítem

Atribución 4.0 Internacional
Excepto si se señala otra cosa, la licencia del ítem se describe como: Atribución 4.0 Internacional