dc.creator | Cruz Ojeda, Patricia de la | es |
dc.creator | Flores-Campos, Rocío | es |
dc.creator | Dios-Barbeito, Sandra | es |
dc.creator | Navarro-Villarán, Elena | es |
dc.creator | Muntané Relat, Jordi | es |
dc.date.accessioned | 2022-11-10T13:57:04Z | |
dc.date.available | 2022-11-10T13:57:04Z | |
dc.date.issued | 2021-06-10 | |
dc.identifier.citation | Cruz Ojeda, P.d.l., Flores-Campos, R., Dios-Barbeito, S., Navarro-Villarán, E. y Muntané Relat, J. (2021). Role of nitric oxide in gene expression regulation during cancer: epigenetic modifications and non-coding RNAs. International Journal of Molecular Sciences, 22 (12), 6264. https://doi.org/10.3390/ijms22126264. | |
dc.identifier.issn | 1422-0067 | es |
dc.identifier.uri | https://hdl.handle.net/11441/139250 | |
dc.description.abstract | Nitric oxide (NO) has been identified and described as a dual mediator in cancer according
to dose-, time- and compartment-dependent NO generation. The present review addresses the
different epigenetic mechanisms, such as histone modifications and non-coding RNAs (ncRNAs),
miRNA and lncRNA, which regulate directly or indirectly nitric oxide synthase (NOS) expression and
NO production, impacting all hallmarks of the oncogenic process. Among lncRNA, HEIH and UCA1
develop their oncogenic functions by inhibiting their target miRNAs and consequently reversing
the inhibition of NOS and promoting tumor proliferation. The connection between miRNAs and
NO is also involved in two important features in cancer, such as the tumor microenvironment that
includes key cellular components such as tumor-associated macrophages (TAMs), cancer associated
fibroblasts (CAFs) and cancer stem cells (CSCs). | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | International Journal of Molecular Sciences, 22 (12), 6264. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Hepatocarcinoma | es |
dc.subject | miRNA | es |
dc.subject | Nitric oxide synthase | es |
dc.subject | lncRNA | es |
dc.subject | Tumor-associated macrophages | es |
dc.subject | Cancer associated fibroblasts | es |
dc.subject | Cancer stem cells | es |
dc.title | Role of nitric oxide in gene expression regulation during cancer: epigenetic modifications and non-coding RNAs | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.relation.projectID | PI19/01266 | es |
dc.relation.projectID | PI-0216-2020 | es |
dc.relation.projectID | FPU17/00026 | es |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/22/12/6264 | es |
dc.identifier.doi | 10.3390/ijms22126264 | es |
dc.journaltitle | International Journal of Molecular Sciences | es |
dc.publication.volumen | 22 | es |
dc.publication.issue | 12 | es |
dc.publication.initialPage | 6264 | es |
dc.contributor.funder | Instituto de Salud Carlos III | es |
dc.contributor.funder | Conserjería de Salud Junta de Andalucía | es |
dc.contributor.funder | Ministerio de Educación, Cultura y Deporte (MECD). España | es |