dc.creator | Ravoitytė, Bazilė | es |
dc.creator | Lukša, Juliana | es |
dc.creator | Wellinger, Ralf Erik | es |
dc.creator | Serva, Saulius | es |
dc.creator | Servienė, Elena | es |
dc.date.accessioned | 2022-10-31T16:21:37Z | |
dc.date.available | 2022-10-31T16:21:37Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Ravoitytė, B., Lukša, J., Wellinger, R.E., Serva, S. y Servienė, E. (2022). Adaptive response of saccharomyces hosts to totiviridae L-A dsRNA viruses Is achieved through intrinsically balanced action of targeted transcription factors. Journal of Fungi, 8 (4), 381. https://doi.org/10.3390/jof8040381. | |
dc.identifier.issn | 2309-608X | es |
dc.identifier.uri | https://hdl.handle.net/11441/138548 | |
dc.description.abstract | Totiviridae L-A virus is a widespread yeast dsRNA virus. The persistence of the L-A virus alone appears to be symptomless, but the concomitant presence of a satellite M virus provides a killer trait for the host cell. The presence of L-A dsRNA is common in laboratory, industrial, and wild yeasts, but little is known about the impact of the L-A virus on the host’s gene expression. In this work, based on high-throughput RNA sequencing data analysis, the impact of the L-A virus on whole-genome expression in three different Saccharomyces paradoxus and S. cerevisiae host strains was analyzed. In the presence of the L-A virus, moderate alterations in gene expression were detected, with the least impact on respiration-deficient cells. Remarkably, the transcriptional adaptation of essential genes was limited to genes involved in ribosome biogenesis. Transcriptional responses to L-A maintenance were, nevertheless, similar to those induced upon stress or nutrient availability. Based on these data, we further dissected yeast transcriptional regulators that, in turn, modulate the cellular L-A dsRNA levels. Our findings point to totivirus-driven fine-tuning of the transcriptional landscape in yeasts and uncover signaling pathways employed by dsRNA viruses to establish the stable, yet allegedly profitless, viral infection of fungi. | es |
dc.description.sponsorship | Fondo Social Europeo 09.3.3-LMT-K-712-19- 0157 | es |
dc.format | application/pdf | es |
dc.format.extent | 24 p. | es |
dc.language.iso | eng | es |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es |
dc.relation.ispartof | Journal of Fungi, 8 (4), 381. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Totiviridae | es |
dc.subject | dsRNA | es |
dc.subject | Transcription | es |
dc.subject | yeast | es |
dc.subject | Saccharomyces cerevisiae | es |
dc.subject | Saccharomyces paradoxus | es |
dc.title | Adaptive response of saccharomyces hosts to totiviridae L-A dsRNA viruses Is achieved through intrinsically balanced action of targeted transcription factors | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Genética | es |
dc.relation.projectID | 09.3.3-LMT-K-712-19- 0157 | es |
dc.relation.publisherversion | https://doi.org/10.3390/jof8040381 | es |
dc.identifier.doi | 10.3390/jof8040381 | es |
dc.journaltitle | Journal of Fungi | es |
dc.publication.volumen | 8 | es |
dc.publication.issue | 4 | es |
dc.publication.initialPage | 381 | es |
dc.contributor.funder | Fondo Social Europeo (FSO) | es |