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dc.creatorRaue, Rebeccaes
dc.creatorFrank, Ann Christines
dc.creatorFuhrmann, Dominik C.es
dc.creatorCruz Ojeda, Patricia de laes
dc.creatorRösser, Silviaes
dc.creatorBauer, Rebekkaes
dc.creatorBrüne, Bernhardes
dc.date.accessioned2022-10-25T17:48:37Z
dc.date.available2022-10-25T17:48:37Z
dc.date.issued2022
dc.identifier.citationRaue, R., Frank, A.C., Fuhrmann, D.C., De la Cruz Ojeda, P., Rösser, S., Bauer, R. y Brüne, B. (2022). MicroRNA-200c Attenuates the Tumor-Infiltrating Capacity of Macrophages. Biology, 11 (3), 349. https://doi.org/10.3390/biology11030349.
dc.identifier.issn2079-7737es
dc.identifier.urihttps://hdl.handle.net/11441/138317
dc.description.abstractMacrophages constitute a major part of the tumor-infiltrating immune cells. Within the tumor microenvironment, they acquire an alternatively activated, tumor-supporting phenotype. Factors released by tumor cells are crucial for the recruitment of tumor-associated macrophages. In the present project, we aimed to understand the role of hsa-miR-200c-3p (miR-200c) in the interplay between tumor cells and macrophages. To this end, we employed a coculture system of MCF7 breast tumor cells and primary human macrophages and observed the transfer of miR-200c from apoptotic tumor cells to macrophages, which required intact CD36 receptor in macrophages. We further comprehensively determined miR-200c targets in macrophages by mRNA-sequencing and identified numerous migration-associated mRNAs to be downregulated by miR-200c. Consequently, miR-200c attenuated macrophage infiltration into 3-dimensional tumor spheroids. miR-200c-mediated reduction in infiltration further correlated with a miR-200c migration signature comprised of the four miR-200c-repressed, predicted targets PPM1F, RAB11FIB2, RDX, and MSN.es
dc.formatapplication/pdfes
dc.format.extent16 p.es
dc.language.isoenges
dc.publisherMDPIes
dc.relation.ispartofBiology, 11 (3), 349.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMacrophagees
dc.subjectBreast tumores
dc.subjectMiRes
dc.subjectTumor microenvironmentes
dc.titleMicroRNA-200c Attenuates the Tumor-Infiltrating Capacity of Macrophageses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Fisiología Médica y Biofísicaes
dc.relation.publisherversionhttps://www.mdpi.com/2079-7737/11/3/349es
dc.identifier.doi10.3390/biology11030349es
dc.journaltitleBiologyes
dc.publication.volumen11es
dc.publication.issue3es
dc.publication.initialPage349es

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