dc.creator | Raue, Rebecca | es |
dc.creator | Frank, Ann Christin | es |
dc.creator | Fuhrmann, Dominik C. | es |
dc.creator | Cruz Ojeda, Patricia de la | es |
dc.creator | Rösser, Silvia | es |
dc.creator | Bauer, Rebekka | es |
dc.creator | Brüne, Bernhard | es |
dc.date.accessioned | 2022-10-25T17:48:37Z | |
dc.date.available | 2022-10-25T17:48:37Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Raue, R., Frank, A.C., Fuhrmann, D.C., De la Cruz Ojeda, P., Rösser, S., Bauer, R. y Brüne, B. (2022). MicroRNA-200c Attenuates the Tumor-Infiltrating Capacity of Macrophages. Biology, 11 (3), 349. https://doi.org/10.3390/biology11030349. | |
dc.identifier.issn | 2079-7737 | es |
dc.identifier.uri | https://hdl.handle.net/11441/138317 | |
dc.description.abstract | Macrophages constitute a major part of the tumor-infiltrating immune cells. Within the tumor microenvironment, they acquire an alternatively activated, tumor-supporting phenotype. Factors released by tumor cells are crucial for the recruitment of tumor-associated macrophages. In the present project, we aimed to understand the role of hsa-miR-200c-3p (miR-200c) in the interplay between tumor cells and macrophages. To this end, we employed a coculture system of MCF7 breast tumor cells and primary human macrophages and observed the transfer of miR-200c from apoptotic tumor cells to macrophages, which required intact CD36 receptor in macrophages. We further comprehensively determined miR-200c targets in macrophages by mRNA-sequencing and identified numerous migration-associated mRNAs to be downregulated by miR-200c. Consequently, miR-200c attenuated macrophage infiltration into 3-dimensional tumor spheroids. miR-200c-mediated reduction in infiltration further correlated with a miR-200c migration signature comprised of the four miR-200c-repressed, predicted targets PPM1F, RAB11FIB2, RDX, and MSN. | es |
dc.format | application/pdf | es |
dc.format.extent | 16 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Biology, 11 (3), 349. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Macrophage | es |
dc.subject | Breast tumor | es |
dc.subject | MiR | es |
dc.subject | Tumor microenvironment | es |
dc.title | MicroRNA-200c Attenuates the Tumor-Infiltrating Capacity of Macrophages | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.relation.publisherversion | https://www.mdpi.com/2079-7737/11/3/349 | es |
dc.identifier.doi | 10.3390/biology11030349 | es |
dc.journaltitle | Biology | es |
dc.publication.volumen | 11 | es |
dc.publication.issue | 3 | es |
dc.publication.initialPage | 349 | es |