Artículo
Examining the relationship between altered brain functional connectome and disinhibition across 33 impulsive and compulsive behaviours
Autor/es | Chye, Yann
Suo, Chao Romero García, Rafael Bethlehem, Richard A. I. Hook, Roxanne Tiego, Jeggan Chamberlain, Samuel R. |
Departamento | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica |
Fecha de publicación | 2022 |
Fecha de depósito | 2022-10-19 |
Publicado en |
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Resumen | Impulsive and compulsive problem behaviours are associated with a variety of mental disorders. Latent phenotyping indicates the expression of impulsive and compulsive problem behaviours is predominantly governed by a ... Impulsive and compulsive problem behaviours are associated with a variety of mental disorders. Latent phenotyping indicates the expression of impulsive and compulsive problem behaviours is predominantly governed by a transdiagnostic ‘disinhibition’ phenotype. In a cohort of 117 individuals, recruited as part of the Neuroscience in Psychiatry Network (NSPN), we examined how brain functional connectome and network properties relate to disinhibition. Reduced functional connectivity within a subnetwork of frontal (especially right inferior frontal gyrus), occipital and parietal regions was linked to disinhibition. Findings provide insights into neurobiological pathways underlying the emergence of impulsive and compulsive disorders. |
Cita | Chye, Y., Suo, C., Romero García, R., Bethlehem, R.A.I., Hook, R., Tiego, J. y Chamberlain, S.R. (2022). Examining the relationship between altered brain functional connectome and disinhibition across 33 impulsive and compulsive behaviours. British Journal of Psichiatry, 220 (2), 76-78. https://doi.org/10.1192/bjp.2021.49. |
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