dc.creator | Poologaindran, Anujan | es |
dc.creator | Profyris, Christos | es |
dc.creator | Young, Isabella M. | es |
dc.creator | Dadario, Nicholas B. | es |
dc.creator | Ahsan, Syed A. | es |
dc.creator | Chendeb, Kassem | es |
dc.creator | Briggs, Robert G. | es |
dc.creator | Teo, Charles | es |
dc.creator | Romero García, Rafael | es |
dc.creator | Suckling, John | es |
dc.creator | Sughrue, Michael E. | es |
dc.date.accessioned | 2022-10-19T13:59:20Z | |
dc.date.available | 2022-10-19T13:59:20Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Poologaindran, A., Profyris, C., Young, I.M., Dadario, N.B., Ahsan, S.A., Chendeb, K.,...,Sughrue, M.E. (2022). Interventional neurorehabilitation for promoting functional recovery post-craniotomy: a proof-of-concept. Scientific Reports, 12 (1), 3039. https://doi.org/10.1038/s41598-022-06766-8. | |
dc.identifier.issn | 2045-2322 | es |
dc.identifier.uri | https://hdl.handle.net/11441/138115 | |
dc.description.abstract | The human brain is a highly plastic ‘complex’ network—it is highly resilient to damage and capable of self-reorganisation after a large perturbation. Clinically, neurological deficits secondary to iatrogenic injury have very few active treatments. New imaging and stimulation technologies, though, offer promising therapeutic avenues to accelerate post-operative recovery trajectories. In this study, we sought to establish the safety profile for ‘interventional neurorehabilitation’: connectome-based therapeutic brain stimulation to drive cortical reorganisation and promote functional recovery post-craniotomy. In n = 34 glioma patients who experienced post-operative motor or language deficits, we used connectomics to construct single-subject cortical networks. Based on their clinical and connectivity deficit, patients underwent network-specific transcranial magnetic stimulation (TMS) sessions daily over five consecutive days. Patients were then assessed for TMS-related side effects and improvements. 31/34 (91%) patients were successfully recruited and enrolled for TMS treatment within two weeks of glioma surgery. No seizures or serious complications occurred during TMS rehabilitation and 1-week post-stimulation. Transient headaches were reported in 4/31 patients but improved after a single session. No neurological worsening was observed while a clinically and statistically significant benefit was noted in 28/31 patients post-TMS. We present two clinical vignettes and a video demonstration of interventional neurorehabilitation. For the first time, we demonstrate the safety profile and ability to recruit, enroll, and complete TMS acutely post-craniotomy in a high seizure risk population. Given the lack of randomisation and controls in this study, prospective randomised sham-controlled stimulation trials are now warranted to establish the efficacy of interventional neurorehabilitation following craniotomy. | es |
dc.format | application/pdf | es |
dc.format.extent | 11 p. | es |
dc.language.iso | eng | es |
dc.publisher | Nature Publishing Group | es |
dc.relation.ispartof | Scientific Reports, 12 (1), 3039. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Human brain | es |
dc.subject | Interventional neurorehabilitation | es |
dc.subject | Functional recovery post-craniotomy | es |
dc.subject | Transcranial magnetic stimulation (TMS) | es |
dc.title | Interventional neurorehabilitation for promoting functional recovery post-craniotomy: a proof-of-concept | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.relation.publisherversion | https://www.nature.com/articles/s41598-022-06766-8 | es |
dc.identifier.doi | 10.1038/s41598-022-06766-8 | es |
dc.journaltitle | Scientific Reports | es |
dc.publication.volumen | 12 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 3039 | es |