dc.creator | Trillo Contreras, José Luis | es |
dc.creator | Ramírez Lorca, Reposo | es |
dc.creator | Villadiego Luque, Francisco Javier | es |
dc.creator | Echevarría Irusta, Miriam | es |
dc.date.accessioned | 2022-10-18T13:57:43Z | |
dc.date.available | 2022-10-18T13:57:43Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Trillo Contreras, J.L., Ramírez Lorca, R., Villadiego Luque, F.J. y Echevarría Irusta, M. (2022). Cellular distribution of brain aquaporins and their contribution to cerebrospinal fluid homeostasis and hydrocephalus. Biomolecules, 12 (4), 1-18. https://doi.org/10.3390/biom12040530. | |
dc.identifier.issn | 2218-273X | es |
dc.identifier.uri | https://hdl.handle.net/11441/138038 | |
dc.description.abstract | Brain aquaporins facilitate the movement of water between the four water compartments:
blood, cerebrospinal fluid, interstitial fluid, and intracellular fluid. This work analyzes the expression
of the four most abundant aquaporins (AQPs) (AQP1, AQP4, AQP9, and AQP11) in the brains of
mice and discuss their contribution to hydrocephalus. We analyzed available data from single-cell
RNA sequencing of the central nervous system of mice to describe the expression of aquaporins
and compare their distribution with that based on qPCR, western blot, and immunohistochemistry
assays. Expression of AQP1 in the apical cell membrane of choroid plexus epithelial cells and of
AQP4 in ependymal cells, glia limitans, and astrocyte processes in the pericapillary end foot is
consistent with the involvement of both proteins in cerebrospinal fluid homeostasis. The expression
of both aquaporins compensates for experimentally induced hydrocephalus in the animals. Recent
data demonstrate that hypoxia in aged animals alters AQP4 expression in the choroidal plexus and
cortex, increasing the ventricle size and intraventricular pressure. Cerebral distensibility is reduced in
parallel with a reduction in cerebrospinal fluid drainage and cognitive deterioration. We propose that
aged mice chronically exposed to hypoxia represent an excellent experimental model for studying the
pathophysiological characteristics of idiopathic normal pressure hydrocephalus and roles for AQPs
in such disease. | es |
dc.format | application/pdf | es |
dc.format.extent | 18 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Biomolecules, 12 (4), 1-18. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Aquaporins | es |
dc.subject | Cerebrospinal fluid | es |
dc.subject | Choroid plexus | es |
dc.subject | Ependyma | es |
dc.subject | Single-cell RNA | es |
dc.subject | Sequencing | es |
dc.subject | Hydrocephalus | es |
dc.subject | Aging | es |
dc.subject | Hypoxia | es |
dc.title | Cellular distribution of brain aquaporins and their contribution to cerebrospinal fluid homeostasis and hydrocephalus | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.relation.publisherversion | https://www.mdpi.com/2218-273X/12/4/530 | es |
dc.identifier.doi | 10.3390/biom12040530 | es |
dc.journaltitle | Biomolecules | es |
dc.publication.volumen | 12 | es |
dc.publication.issue | 4 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 18 | es |