dc.creator | Gadomski, Stephen | es |
dc.creator | Fielding, Claire | es |
dc.creator | García García, Andrés | es |
dc.creator | Korn, Claudia | es |
dc.creator | Kapeni, Chrysa | es |
dc.creator | Ashraf, Sadaf | es |
dc.creator | Villadiego Luque, Francisco Javier | es |
dc.creator | Toro Estévez, Raquel del | es |
dc.creator | Toledo Aral, Juan José | es |
dc.creator | Méndez Ferrer, Simón | es |
dc.date.accessioned | 2022-10-14T14:43:18Z | |
dc.date.available | 2022-10-14T14:43:18Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Gadomski, S., Fielding, C., García García, A., Korn, C., Kapeni, C., Ashraf, S.,...,Méndez Ferrer, S. (2022). A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise.. Cell Stem Cell, 29 (4), 528-544.e9. https://doi.org/10.1016/j.stem.2022.02.008. | |
dc.identifier.issn | 1875-9777 | es |
dc.identifier.issn | 1934-5909 | es |
dc.identifier.uri | https://hdl.handle.net/11441/137924 | |
dc.description.abstract | The autonomic nervous system is a master regulator of homeostatic processes and stress responses. Sym pathetic noradrenergic nerve fibers decrease bone mass, but the role of cholinergic signaling in bone has
remained largely unknown. Here, we describe that early postnatally, a subset of sympathetic nerve fibers un dergoes an interleukin-6 (IL-6)-induced cholinergic switch upon contacting the bone. A neurotrophic depen dency mediated through GDNF-family receptor-a2 (GFRa2) and its ligand, neurturin (NRTN), is established
between sympathetic cholinergic fibers and bone-embedded osteocytes, which require cholinergic innerva tion for their survival and connectivity. Bone-lining osteoprogenitors amplify and propagate cholinergic
signals in the bone marrow (BM). Moderate exercise augments trabecular bone partly through an IL-6-depen dent expansion of sympathetic cholinergic nerve fibers. Consequently, loss of cholinergic skeletal innerva tion reduces osteocyte survival and function, causing osteopenia and impaired skeletal adaptation to mod erate exercise. These results uncover a cholinergic neuro-osteocyte interface that regulates skeletogenesis
and skeletal turnover through bone-anabolic effects. | es |
dc.format | application/pdf | es |
dc.format.extent | 27 p. | es |
dc.language.iso | eng | es |
dc.publisher | CELL PRESS (Elsevier) | es |
dc.relation.ispartof | Cell Stem Cell, 29 (4), 528-544.e9. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Postnatal growth | es |
dc.subject | Bone formation | es |
dc.subject | A cholinergic neuroskeletal interface | es |
dc.title | A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise. | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S1934590922000595?via%3Dihub | es |
dc.identifier.doi | 10.1016/j.stem.2022.02.008 | es |
dc.journaltitle | Cell Stem Cell | es |
dc.publication.volumen | 29 | es |
dc.publication.issue | 4 | es |
dc.publication.initialPage | 528 | es |
dc.publication.endPage | 544.e9 | es |