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dc.creatorGadomski, Stephenes
dc.creatorFielding, Clairees
dc.creatorGarcía García, Andréses
dc.creatorKorn, Claudiaes
dc.creatorKapeni, Chrysaes
dc.creatorAshraf, Sadafes
dc.creatorVilladiego Luque, Francisco Javieres
dc.creatorToro Estévez, Raquel deles
dc.creatorToledo Aral, Juan Josées
dc.creatorMéndez Ferrer, Simónes
dc.date.accessioned2022-10-14T14:43:18Z
dc.date.available2022-10-14T14:43:18Z
dc.date.issued2022
dc.identifier.citationGadomski, S., Fielding, C., García García, A., Korn, C., Kapeni, C., Ashraf, S.,...,Méndez Ferrer, S. (2022). A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise.. Cell Stem Cell, 29 (4), 528-544.e9. https://doi.org/10.1016/j.stem.2022.02.008.
dc.identifier.issn1875-9777es
dc.identifier.issn1934-5909es
dc.identifier.urihttps://hdl.handle.net/11441/137924
dc.description.abstractThe autonomic nervous system is a master regulator of homeostatic processes and stress responses. Sym pathetic noradrenergic nerve fibers decrease bone mass, but the role of cholinergic signaling in bone has remained largely unknown. Here, we describe that early postnatally, a subset of sympathetic nerve fibers un dergoes an interleukin-6 (IL-6)-induced cholinergic switch upon contacting the bone. A neurotrophic depen dency mediated through GDNF-family receptor-a2 (GFRa2) and its ligand, neurturin (NRTN), is established between sympathetic cholinergic fibers and bone-embedded osteocytes, which require cholinergic innerva tion for their survival and connectivity. Bone-lining osteoprogenitors amplify and propagate cholinergic signals in the bone marrow (BM). Moderate exercise augments trabecular bone partly through an IL-6-depen dent expansion of sympathetic cholinergic nerve fibers. Consequently, loss of cholinergic skeletal innerva tion reduces osteocyte survival and function, causing osteopenia and impaired skeletal adaptation to mod erate exercise. These results uncover a cholinergic neuro-osteocyte interface that regulates skeletogenesis and skeletal turnover through bone-anabolic effects.es
dc.formatapplication/pdfes
dc.format.extent27 p.es
dc.language.isoenges
dc.publisherCELL PRESS (Elsevier)es
dc.relation.ispartofCell Stem Cell, 29 (4), 528-544.e9.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPostnatal growthes
dc.subjectBone formationes
dc.subjectA cholinergic neuroskeletal interfacees
dc.titleA cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise.es
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Fisiología Médica y Biofísicaes
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1934590922000595?via%3Dihubes
dc.identifier.doi10.1016/j.stem.2022.02.008es
dc.journaltitleCell Stem Celles
dc.publication.volumen29es
dc.publication.issue4es
dc.publication.initialPage528es
dc.publication.endPage544.e9es

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