dc.creator | Palazón Carrión, Natalia | es |
dc.creator | Jiménez Cortegana, Carlos | es |
dc.creator | Sánchez León, María Luisa | es |
dc.creator | Nieto García, María Adoración | es |
dc.creator | Sánchez Margalet, Víctor | es |
dc.creator | Cruz Merino, Luis de la | es |
dc.date.accessioned | 2022-09-28T18:11:41Z | |
dc.date.available | 2022-09-28T18:11:41Z | |
dc.date.issued | 2021-07-13 | |
dc.identifier.citation | Palazón Carrión, N., Jiménez Cortegana, C., Sánchez León, M.L., Nieto García, M.A., Sánchez Margalet, V. y Cruz Merino, L.d.l. (2021). Circulating immune biomarkers in peripheral blood correlate with clinical outcomes in advanced breast cancer. Scientific Reports, 11 (1), 17639. https://doi.org/10.1038/s41598-021-93838-w. | |
dc.identifier.issn | 2045-2322 | es |
dc.identifier.uri | https://hdl.handle.net/11441/137459 | |
dc.description.abstract | Identification of the different elements intervening at the tumor microenvironment seems key to explain clinical evolution in several tumor types. In this study, a set of immune biomarkers (myeloid derived suppressor cells, regulatory T cells, and OX40 + and PD-1 + T lymphocytes counts) in peripheral blood of patients diagnosed with advanced breast cancer were analyzed along of first line antineoplastic therapy. Subsequently, a comparison between groups with clinical benefit versus progression of disease and with a healthy women cohort was executed. Results reflected that patients showed higher basal levels of myeloid derived suppressor cells (35.43, IR = 180.73 vs 17.53, IR = 16.96 cells/μl; p = 0.001) and regulatory T cells (32.05, IR = 29.84 vs 22.61, IR = 13.57 cells/μl; p = 0.001) in comparison with healthy women. Furthermore, an increase in the number of activated T lymphocytes (expressing OX40), a decrease of immune inhibitory cells (MDSCs and Tregs) and inhibited T lymphocytes (expressing PD-1) were observed along the treatment in patients with clinical benefit (p ≤ 0.001). The opposite trend was observed in the case of disease progression. These findings suggest that some critical immune elements can be easily detected and measured in peripheral blood, which open a new opportunity for translational research, as they seem to be correlated with clinical evolution, at least in ABC. | es |
dc.description.sponsorship | Fundación Progreso y Salud. Junta de Andalucía (PI-0502-2014 FPS-2014) | es |
dc.format | application/pdf | es |
dc.format.extent | 12 p. | es |
dc.language.iso | eng | es |
dc.publisher | Nature Publishing Group | es |
dc.relation.ispartof | Scientific Reports, 11 (1), 14426. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Circulating immune biomarkers in peripheral blood correlate with clinical outcomes in advanced breast cancer | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina Preventiva y Salud Pública | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://www.nature.com/articles/s41598-021-93838-w | es |
dc.identifier.doi | 10.1038/s41598-021-93838-w | es |
dc.journaltitle | Scientific Reports | es |
dc.publication.volumen | 11 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 14426 | |