Artículo
Structural optimization of 3D-printed patient-specific ceramic scaffolds for in vivo bone regeneration in load-bearing defects
Autor/es | Blázquez Carmona, Pablo
Sanz Herrera, José Antonio Martínez Vázquez, Francisco Javier Domínguez, Jaime Reina Romo, Esther |
Departamento | Universidad de Sevilla. Departamento de Ingeniería Mecánica y de Fabricación |
Fecha de publicación | 2021 |
Fecha de depósito | 2022-09-07 |
Publicado en |
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Resumen | Tissue engineering has recently gained popularity as an alternative to autografts to stimulate bone tissue
regeneration through structures called scaffolds. Most of the in vivo experiments on long-bony defects ... Tissue engineering has recently gained popularity as an alternative to autografts to stimulate bone tissue regeneration through structures called scaffolds. Most of the in vivo experiments on long-bony defects use internally-stabilized generic scaffolds. Despite the wide variety of computational methods, a standardized protocol is required to optimize ceramic scaffolds for load-bearing bony defects stabilized with flexible fixations. An optimization problem was defined for applications to sheep metatarsus defects. It covers biological parameters (porosity, pore size, and the specific surface area) and mechanical constraints based on in vivo and in vitro results reported in the literature. The optimized parameters (59.30% of porosity, 5768.91 m− 1 of specific surface area, and 360.80 μm of pore size) and the compressive strength of the selected structure were validated in vitro by means of tomographic images and compression tests of six 3D-printed samples. Divergences between the design and measured values of the optimized parameters, mainly due to manufacturing defects, are consistent with the previous studies. Using the mixed experimental-mathematical scaffold-design procedure described, they could be implanted in vivo with instrumented external fixators, therefore facilitating biomechanical monitoring of the regeneration process. |
Agencias financiadoras | Consejería de Economía, Conocimiento, Empresas y Universidad (Junta de Andalucía) |
Identificador del proyecto | DPI2017-82501-P
FPU17/05361 US-1261691 |
Cita | Blázquez Carmona, P., Sanz Herrera, J.A., Martínez Vázquez, F.J., Domínguez, J. y Reina Romo, E. (2021). Structural optimization of 3D-printed patient-specific ceramic scaffolds for in vivo bone regeneration in load-bearing defects. Journal of the Mechanical Behavior of Biomedical Materials, 121, Article number 104613. |
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