Mostrar el registro sencillo del ítem

Artículo

dc.creatorRojas, Ángelaes
dc.creatorGallego, Palomaes
dc.creatorGil Gómez, Antonioes
dc.creatorMuñoz Hernández, Rocíoes
dc.creatorMartín, Lourdeses
dc.creatorGallego Durán, Rocíoes
dc.creatorGarcía Valdecasas, Martaes
dc.creatorCampo, José A. deles
dc.creatorBautista Palomas, Juan Dionisioes
dc.creatorRomero Gómez, Manueles
dc.date.accessioned2022-07-05T11:31:40Z
dc.date.available2022-07-05T11:31:40Z
dc.date.issued2018
dc.identifier.citationRojas, Á., Gallego, P., Gil Gómez, A., Muñoz Hernández, R., Martín, L., Gallego Durán, R.,...,Romero Gómez, M. (2018). Natural Extracts Abolished Lipid Accumulation in Cells Harbouring non-favourable PNPLA3 genotype. Annals of Hepatology, 17 (2), 242-249.
dc.identifier.issn1665-2681es
dc.identifier.urihttps://hdl.handle.net/11441/135003
dc.description.abstractBackground & aims. G-allele of PNPLA3 (rs738409) favours triglycerides accumulation and steatosis. In this study, we examined the effect of quercetin and natural extracts from mushroom and artichoke on reducing lipid accumulation in hepatic cells. Material and methods. Huh7.5 cells were exposed to oleic acid (OA) and treated with quercetin and extracts to observe the lipid accumulation, the intracellular-TG concentration and the LD size. Sterol regulatory element binding proteins-1 (SREBP-1), peroxisome proliferator-activated receptor (PPARα-γ) and cholesterol acyltransferase (ACAT) gene expression levels were analysed. Results. Quercetin decreased the intracellular lipids, LD size and the levels of intracellular-TG through the down-regulation of SREBP-1c, PPARγand ACAT1 increasing PPARα. The natural-extracts suppressed OA-induced lipid accumulation and the intracellular-TG. They down-regulate the hepatic lipogenesis through SREBP-1c, besides the activation of lipolysis through the increasing of PPARα expression. Conclusions. Quercetin and the aqueous extracts decrease intracellular lipid accumulation by down-regulation of lipogenesis and up-regulation of lipolysis.es
dc.formatapplication/pdfes
dc.format.extent8 p.es
dc.language.isoenges
dc.publisherElsevieres
dc.relation.ispartofAnnals of Hepatology, 17 (2), 242-249.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectSteatosises
dc.subjectLipid dropletses
dc.subjectTriglycerideses
dc.subjectQuercetines
dc.subjectCynara scolymuses
dc.subjectAgaricus Bisporuses
dc.subjectMushroomes
dc.subjectArtichokees
dc.titleNatural Extracts Abolished Lipid Accumulation in Cells Harbouring non-favourable PNPLA3 genotypees
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Bioquímica y Biología Moleculares
dc.relation.publisherversionhttps://doi.org/10.5604/01.3001.0010.8642es
dc.identifier.doi10.5604/01.3001.0010.8642es
dc.journaltitleAnnals of Hepatologyes
dc.publication.volumen17es
dc.publication.issue2es
dc.publication.initialPage242es
dc.publication.endPage249es

FicherosTamañoFormatoVerDescripción
1-s2.0-S1665268119301565-main.pdf455.3KbIcon   [PDF] Ver/Abrir  

Este registro aparece en las siguientes colecciones

Mostrar el registro sencillo del ítem

Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Excepto si se señala otra cosa, la licencia del ítem se describe como: Attribution-NonCommercial-NoDerivatives 4.0 Internacional