Article
Hu Antigen R (HuR) Protein Structure, Function and Regulation in Hepatobiliary Tumors
Author/s | Lachiondo Ortega, Sofía
Cardoso Delgado, Teresa Baños Jaime, Blanca Velázquez Cruz, Alejandro Díaz Moreno, Irene Martínez Chantar, María Luz |
Department | Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular |
Publication Date | 2022 |
Deposit Date | 2022-06-13 |
Published in |
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Abstract | Hepatobiliary tumors are a group of primary malignancies encompassing the liver, the intra- and extra-hepatic biliary tracts, and the gall bladder. Within the liver, hepatocellular carcinoma (HCC) is the most common type ... Hepatobiliary tumors are a group of primary malignancies encompassing the liver, the intra- and extra-hepatic biliary tracts, and the gall bladder. Within the liver, hepatocellular carcinoma (HCC) is the most common type of primary cancer, which is, also, representing the third-most recurrent cause of cancer-associated death and the sixth-most prevalent type of tumor worldwide, nowadays. Although less frequent, cholangiocarcinoma (CCA) is, currently, a fatal cancer with limited therapeutic options. Here, we review the regulatory role of Hu antigen R (HuR), a ubiquitous member of the ELAV/Hu family of RNA-binding proteins (RBPs), in the pathogenesis, progression, and treatment of HCC and CCA. Overall, HuR is proposed as a valuable diagnostic and prognostic marker, as well as a therapeutic target in hepatobiliary cancers. Therefore, novel therapeutic approaches that can selectively modulate HuR function appear to be highly attractive for the clinical management of these types of tumors. |
Funding agencies | Ministerio de Ciencia, Innovación y Universidades (MICINN). España Junta de Andalucía European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) Ministerio de Educación, Cultura y Deporte (MECD). España |
Project ID. | PID2020-117116RB-I00 (to M.L.M.-C.) and PGC2018-096049-B-I00
BIO-198, US-1254317, US-1257019, P18-FR-3487, and P18-HO-4091 HR17-00601 FPU016/01513 |
Citation | Lachiondo Ortega, S., Cardoso Delgado, T., Baños Jaime, B., Velázquez Cruz, A., Díaz Moreno, I. y Martínez Chantar, M.L. (2022). Hu Antigen R (HuR) Protein Structure, Function and Regulation in Hepatobiliary Tumors. Cancers, 14 (11), 2666. |
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