dc.creator | Rodríguez Salamanca, Patricia | es |
dc.creator | Martín de la Calle, Rocío | es |
dc.creator | Rodríguez Bravo, Verónica | es |
dc.creator | Merino, Pedro | es |
dc.creator | Fernández Fernández, Rosario Fátima | es |
dc.creator | Lassaletta, José M. | es |
dc.creator | Hornillos, Valentín | es |
dc.date.accessioned | 2022-03-22T13:44:36Z | |
dc.date.available | 2022-03-22T13:44:36Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Rodríguez Salamanca, P., Martín de la Calle, R., Rodríguez Bravo, V., Merino, P., Fernández Fernández, R.F., Lassaletta, J.M. y Hornillos, V. (2021). Asymmetric synthesis of dibenzo[b,d]azepines by Cu-catalyzed reductive or borylative cyclization. Chemical Science, 12 (46), 15291-15297. | |
dc.identifier.issn | 2041-6520 impreso | es |
dc.identifier.issn | 2041-6539 electrónico | es |
dc.identifier.uri | https://hdl.handle.net/11441/131149 | |
dc.description.abstract | A copper-catalyzed asymmetric intramolecular reductive cyclization for the synthesis of dibenzo[b,d]azepines is described. Use of 2′-vinyl-biaryl-2-imines as substrates and in situ formed [CuI/(Ph-BPE)] as the catalyst enables the synthesis of 7-membered bridged biarylamines containing both central and axial stereogenic elements in high yields (up to 98%) and with excellent diastereo- and enantioselectivities (>20 : 1 d.r., up to 99% ee). Moreover, the same catalyst was found to facilitate a related borylative cyclization to afford versatile boronic ester derivatives. Both reactions proceed under mild conditions (rt) and are applicable to a variety of substituted aromatic and heterocyclic derivatives. | es |
dc.description.sponsorship | Junta de Andalucía (Grants P18-FR-3531, P18-FR-644, US1262867 and US-1260906) | es |
dc.description.sponsorship | Aragon Government (Grupos E34_20R) | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación (Grants PID2019-106358GB-C21, PID2019-106358GB-C22, PID2019-104090RB-100) | es |
dc.format | application/pdf | es |
dc.format.extent | 7 p. | es |
dc.language.iso | eng | es |
dc.publisher | Royal Society of Chemistry | es |
dc.relation.ispartof | Chemical Science, 12 (46), 15291-15297. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Asymmetric synthesis of dibenzo[b,d]azepines by Cu-catalyzed reductive or borylative cyclization | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química orgánica | es |
dc.relation.projectID | PID2019-106358GB-C21 | es |
dc.relation.projectID | PID2019-106358GB-C22 | es |
dc.relation.projectID | PID2019-104090RB-100 | es |
dc.relation.projectID | E34_20R | es |
dc.relation.projectID | P18-FR-3531 | es |
dc.relation.projectID | P18-FR-644 | es |
dc.relation.projectID | US1262867 | es |
dc.relation.projectID | US-1260906 | es |
dc.relation.publisherversion | http://dx.doi.org/10.1039/d1sc04980a | es |
dc.identifier.doi | 10.1039/d1sc04980a | es |
dc.journaltitle | Chemical Science | es |
dc.publication.volumen | 12 | es |
dc.publication.issue | 46 | es |
dc.publication.initialPage | 15291 | es |
dc.publication.endPage | 15297 | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | es |
dc.contributor.funder | Junta de Andalucía | es |
dc.contributor.funder | Gobierno de Aragón | es |