dc.creator | García Muriana, Francisco José | es |
dc.creator | Montserrat de la Paz, Sergio | es |
dc.creator | Lucas Rodríguez, Ricardo | es |
dc.creator | Bermúdez Pulgarín, Beatriz | es |
dc.creator | Jaramillo Carmona, Sara | es |
dc.creator | Morales, Juan C. | es |
dc.creator | Abia González, María del Rocío | es |
dc.creator | López Martín, Sergio | es |
dc.date.accessioned | 2022-03-09T14:55:28Z | |
dc.date.available | 2022-03-09T14:55:28Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | García Muriana, F.J., Montserrat de la Paz, S., Lucas Rodríguez, R., Bermúdez Pulgarín, B., Jaramillo Carmona, S., Morales, J.C.,...,López Martín, S. (2017). Tyrosol and its metabolites as antioxidative and anti-inflammatory molecules in human endothelial cells. Food and Function, 8 (8), 2905-2914. | |
dc.identifier.issn | 2042-6496 | es |
dc.identifier.issn | 2042-650X | es |
dc.identifier.uri | https://hdl.handle.net/11441/130623 | |
dc.description.abstract | Tyrosol (Tyr) is a phenolic compound found in virgin olive oil. After ingestion, Tyr undergoes extensive first pass intestinal/hepatic metabolism. However, knowledge about the biological effects of Tyr metabolites is scarce. We chemically synthesized Tyr glucuronate (Tyr-GLU) and sulphate (Tyr-SUL) metabolites and explored their properties against oxidative stress and inflammation in TNF-α-treated human umbilical vein endothelial cells (hECs). Tyr and Tyr-SUL prevented the rise of reactive oxygen species, the depletion of glutathione, and the down-regulation of glutathione peroxidase 1, glutamate-cysteine ligase catalytic subunit, and heme oxygenase-1 genes. Tyr-SUL and to a lower extent Tyr and Tyr-GLU prevented the phosphorylation of NF-κB signaling proteins. Tyr-GLU and Tyr-SUL also prevented the over-expression of adhesion molecules at gene, protein, and secretory levels, and the adhesion (Tyr-SUL > Tyr-GLU) of human monocytes to hECs. In vivo, Tyr, and most notably Tyr-SUL in a dose-dependent manner, ameliorated plantar and ear edemas in mice models of acute and chronic inflammation. This study demonstrates the antioxidant and/or anti-inflammatory properties of Tyr metabolites, with Tyr-SUL being the most effective. | es |
dc.description.sponsorship | Junta de Andalucía P09-CVI-5007 | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad JCI-2012-13084 | es |
dc.format | application/pdf | es |
dc.format.extent | 22 p. | es |
dc.language.iso | eng | es |
dc.publisher | Royal Society of Chemistry | es |
dc.relation.ispartof | Food and Function, 8 (8), 2905-2914. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Tyrosol and its metabolites as antioxidative and anti-inflammatory molecules in human endothelial cells | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Biología Celular | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.relation.projectID | P09-CVI-5007 | es |
dc.relation.projectID | JCI-2012-13084 | es |
dc.relation.publisherversion | https://doi.org/10.1039/C7FO00641A | es |
dc.identifier.doi | 10.1039/C7FO00641A | es |
dc.journaltitle | Food and Function | es |
dc.publication.volumen | 8 | es |
dc.publication.issue | 8 | es |
dc.publication.initialPage | 2905 | es |
dc.publication.endPage | 2914 | es |