Article
Tyrosol and its metabolites as antioxidative and anti-inflammatory molecules in human endothelial cells
Author/s | García Muriana, Francisco José
Montserrat de la Paz, Sergio ![]() ![]() ![]() ![]() ![]() ![]() ![]() Lucas Rodríguez, Ricardo ![]() ![]() ![]() ![]() ![]() ![]() Bermúdez Pulgarín, Beatriz ![]() ![]() ![]() ![]() ![]() ![]() Jaramillo Carmona, Sara Morales, Juan C. Abia González, María del Rocío López Martín, Sergio ![]() ![]() ![]() ![]() ![]() ![]() |
Department | Universidad de Sevilla. Departamento de Biología Celular Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología |
Publication Date | 2017 |
Deposit Date | 2022-03-09 |
Published in |
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Abstract | Tyrosol (Tyr) is a phenolic compound found in virgin olive oil. After ingestion, Tyr undergoes extensive first pass intestinal/hepatic metabolism. However, knowledge about the biological effects of Tyr metabolites is scarce. ... Tyrosol (Tyr) is a phenolic compound found in virgin olive oil. After ingestion, Tyr undergoes extensive first pass intestinal/hepatic metabolism. However, knowledge about the biological effects of Tyr metabolites is scarce. We chemically synthesized Tyr glucuronate (Tyr-GLU) and sulphate (Tyr-SUL) metabolites and explored their properties against oxidative stress and inflammation in TNF-α-treated human umbilical vein endothelial cells (hECs). Tyr and Tyr-SUL prevented the rise of reactive oxygen species, the depletion of glutathione, and the down-regulation of glutathione peroxidase 1, glutamate-cysteine ligase catalytic subunit, and heme oxygenase-1 genes. Tyr-SUL and to a lower extent Tyr and Tyr-GLU prevented the phosphorylation of NF-κB signaling proteins. Tyr-GLU and Tyr-SUL also prevented the over-expression of adhesion molecules at gene, protein, and secretory levels, and the adhesion (Tyr-SUL > Tyr-GLU) of human monocytes to hECs. In vivo, Tyr, and most notably Tyr-SUL in a dose-dependent manner, ameliorated plantar and ear edemas in mice models of acute and chronic inflammation. This study demonstrates the antioxidant and/or anti-inflammatory properties of Tyr metabolites, with Tyr-SUL being the most effective. |
Project ID. | P09-CVI-5007
![]() JCI-2012-13084 ![]() |
Citation | García Muriana, F.J., Montserrat de la Paz, S., Lucas Rodríguez, R., Bermúdez Pulgarín, B., Jaramillo Carmona, S., Morales, J.C.,...,López Martín, S. (2017). Tyrosol and its metabolites as antioxidative and anti-inflammatory molecules in human endothelial cells. Food and Function, 8 (8), 2905-2914. |
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