dc.creator | Alvarez Laderas, Isabel | es |
dc.creator | Ramos, Teresa L. | es |
dc.creator | Medrano, Mayte | es |
dc.creator | Caracuel García, Rocío | es |
dc.creator | Barbado, María Victoria | es |
dc.creator | Sánchez Hidalgo, Marina | es |
dc.creator | Zamora, Rosario | es |
dc.creator | Alarcón de la Lastra Romero, Catalina | es |
dc.creator | Hidalgo, Francisco J. | es |
dc.creator | Piruat, José Ignacio | es |
dc.creator | Caballero Velázquez, Teresa | es |
dc.creator | Pérez Simón, José Antonio | es |
dc.date.accessioned | 2021-12-27T10:29:18Z | |
dc.date.available | 2021-12-27T10:29:18Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Alvarez Laderas, I., Ramos, T.L., Medrano, M., Caracuel García, R., Barbado, M.V., Sánchez Hidalgo, M.,...,Pérez Simón, J.A. (2020). Polyphenolic Extract (PE) from Olive Oil Exerts a Potent Immunomodulatory Effect and Prevents Graft-versus-Host Disease in a Mouse Model. Biology of Blood and Marrow Transplantation, 26 (4), 615-624. | |
dc.identifier.issn | 1083-8791 | es |
dc.identifier.uri | https://hdl.handle.net/11441/128570 | |
dc.description.abstract | Polyphenols are a group of chemical substances found in plants, with immunomodulatory, antiproliferative, and anti-inflammatory properties that might be useful in the prophylaxis and treatment of graft-versus-host disease (GVHD). Polyphenolic extract (PE) obtained from extra virgin olive oil (EVOO) decreased the activation and proliferation of activated T cells. In addition, a decreased production of proinflammatory cytokines was observed upon exposure to PE. Western blot assays showed a marked inhibition of Akt phosphorylation and nuclear translocation of NF-κB in activated T cells. In a murine model of acute GVHD, we observed that mice that received a diet supplemented in PE (600 ppm) presented a higher survival rate and lower risk of developing GVHD when compared with the group that received a control diet. Histopathologic examination showed a significantly lower gut involvement in mice receiving PE, with a decrease in proinflammatory cytokines (IL-2, IL-17, and TNF-α) in serum and the reestablishment of butyrate concentration in the gut. In conclusion, PE obtained from EVOO exerted a potent immunomodulatory effect, reducing the activation and proliferation of activated T cells and the production of proinflammatory cytokines. In a murine model of acute GVHD, a PE-supplemented diet reduced the incidence and severity of the disease and increased survival after transplantation. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 p. | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Biology of Blood and Marrow Transplantation, 26 (4), 615-624. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Graft-versus-host disease | es |
dc.subject | Mouse model | es |
dc.subject | Virgin olive oil | es |
dc.subject | Polyphenolic extract | es |
dc.title | Polyphenolic Extract (PE) from Olive Oil Exerts a Potent Immunomodulatory Effect and Prevents Graft-versus-Host Disease in a Mouse Model | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacología | es |
dc.relation.publisherversion | https://doi.org/10.1016/j.bbmt.2019.11.019 | es |
dc.identifier.doi | 10.1016/j.bbmt.2019.11.019 | es |
dc.journaltitle | Biology of Blood and Marrow Transplantation | es |
dc.publication.volumen | 26 | es |
dc.publication.issue | 4 | es |
dc.publication.initialPage | 615 | es |
dc.publication.endPage | 624 | es |