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The effect of atypical nucleic acids structures in DNA double strand break repair: a tale of R-loops and G-quadruplexes

dc.creatorCamarillo Daza, María Rosaes
dc.creatorJimeno González, Soniaes
dc.creatorHuertas Sánchez, Pabloes
dc.date.accessioned2021-11-11T16:05:05Z
dc.date.available2021-11-11T16:05:05Z
dc.date.issued2021
dc.identifier.citationCamarillo Daza, M.R., Jimeno González, S. y Huertas Sánchez, P. (2021). The effect of atypical nucleic acids structures in DNA double strand break repair: a tale of R-loops and G-quadruplexes. Frontiers in Genetics, 12, 742434.
dc.identifier.issn1664-8021es
dc.identifier.urihttps://hdl.handle.net/11441/127275
dc.description.abstractThe fine tuning of the DNA double strand break repair pathway choice relies on different regulatory layers that respond to environmental and local cues. Among them, the presence of non-canonical nucleic acids structures seems to create challenges for the repair of nearby DNA double strand breaks. In this review, we focus on the recently published effects of G-quadruplexes and R-loops on DNA end resection and homologous recombination. Finally, we hypothesized a connection between those two atypical DNA structures in inhibiting the DNA end resection step of HR.es
dc.description.sponsorshipMinisterio de Ciencia e Innovación PID 2019-104195Ges
dc.formatapplication/pdfes
dc.format.extent10 p.es
dc.language.isoenges
dc.publisherFrontiers Media S.A.es
dc.relation.ispartofFrontiers in Genetics, 12, 742434.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectDNA double strand break repaires
dc.subjectDNA end resectiones
dc.subjectG-quadruplexes
dc.subjectHomologous recombination (HR)es
dc.subjectR-loopses
dc.titleThe effect of atypical nucleic acids structures in DNA double strand break repair: a tale of R-loops and G-quadruplexeses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Genéticaes
dc.relation.projectIDPID 2019-104195Ges
dc.relation.projectID10.13039/501100011033es
dc.relation.publisherversionhttps://doi.org/10.3389/fgene.2021.742434es
dc.identifier.doi10.3389/fgene.2021.742434es
dc.journaltitleFrontiers in Geneticses
dc.publication.volumen12es
dc.publication.initialPage742434es
dc.contributor.funderAgencia Estatal de Investigación. España 10.13039/501100011033es

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