dc.creator | Camarillo Daza, María Rosa | es |
dc.creator | Jimeno González, Sonia | es |
dc.creator | Huertas Sánchez, Pablo | es |
dc.date.accessioned | 2021-11-11T16:05:05Z | |
dc.date.available | 2021-11-11T16:05:05Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Camarillo Daza, M.R., Jimeno González, S. y Huertas Sánchez, P. (2021). The effect of atypical nucleic acids structures in DNA double strand break repair: a tale of R-loops and G-quadruplexes. Frontiers in Genetics, 12, 742434. | |
dc.identifier.issn | 1664-8021 | es |
dc.identifier.uri | https://hdl.handle.net/11441/127275 | |
dc.description.abstract | The fine tuning of the DNA double strand break repair pathway choice relies on different regulatory layers that respond to environmental and local cues. Among them, the presence of non-canonical nucleic acids structures seems to create challenges for the repair of nearby DNA double strand breaks. In this review, we focus on the recently published effects of G-quadruplexes and R-loops on DNA end resection and homologous recombination. Finally, we hypothesized a connection between those two atypical DNA structures in inhibiting the DNA end resection step of HR. | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación PID 2019-104195G | es |
dc.format | application/pdf | es |
dc.format.extent | 10 p. | es |
dc.language.iso | eng | es |
dc.publisher | Frontiers Media S.A. | es |
dc.relation.ispartof | Frontiers in Genetics, 12, 742434. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | DNA double strand break repair | es |
dc.subject | DNA end resection | es |
dc.subject | G-quadruplex | es |
dc.subject | Homologous recombination (HR) | es |
dc.subject | R-loops | es |
dc.title | The effect of atypical nucleic acids structures in DNA double strand break repair: a tale of R-loops and G-quadruplexes | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Genética | es |
dc.relation.projectID | PID 2019-104195G | es |
dc.relation.projectID | 10.13039/501100011033 | es |
dc.relation.publisherversion | https://doi.org/10.3389/fgene.2021.742434 | es |
dc.identifier.doi | 10.3389/fgene.2021.742434 | es |
dc.journaltitle | Frontiers in Genetics | es |
dc.publication.volumen | 12 | es |
dc.publication.initialPage | 742434 | es |
dc.contributor.funder | Agencia Estatal de Investigación. España 10.13039/501100011033 | es |