Article
The effect of atypical nucleic acids structures in DNA double strand break repair: a tale of R-loops and G-quadruplexes
Author/s | Camarillo Daza, María Rosa
Jimeno González, Sonia ![]() ![]() ![]() ![]() ![]() ![]() Huertas Sánchez, Pablo ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
Department | Universidad de Sevilla. Departamento de Genética |
Publication Date | 2021 |
Deposit Date | 2021-11-11 |
Published in |
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Abstract | The fine tuning of the DNA double strand break repair pathway choice relies on different regulatory layers that respond to environmental and local cues. Among them, the presence of non-canonical nucleic acids structures ... The fine tuning of the DNA double strand break repair pathway choice relies on different regulatory layers that respond to environmental and local cues. Among them, the presence of non-canonical nucleic acids structures seems to create challenges for the repair of nearby DNA double strand breaks. In this review, we focus on the recently published effects of G-quadruplexes and R-loops on DNA end resection and homologous recombination. Finally, we hypothesized a connection between those two atypical DNA structures in inhibiting the DNA end resection step of HR. |
Funding agencies | Agencia Estatal de Investigación. España 10.13039/501100011033 |
Project ID. | PID 2019-104195G
![]() 10.13039/501100011033 ![]() |
Citation | Camarillo Daza, M.R., Jimeno González, S. y Huertas Sánchez, P. (2021). The effect of atypical nucleic acids structures in DNA double strand break repair: a tale of R-loops and G-quadruplexes. Frontiers in Genetics, 12, 742434. |
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