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dc.creatorCarrasco Hernández, Lauraes
dc.creatorCaballero Eraso, Candelaes
dc.creatorRuiz Duque, Borjaes
dc.creatorAbad Arranz, Maríaes
dc.creatorMárquez Martín, Eduardoes
dc.creatorCalero Acuña, Carmenes
dc.creatorLópez-Campos Bodineau, José Luises
dc.date.accessioned2021-09-09T12:10:56Z
dc.date.available2021-09-09T12:10:56Z
dc.date.issued2021-04-15
dc.identifier.citationCarrasco Hernández, L., Caballero Eraso, C., Ruiz Duque, B., Abad Arranz, M., Márquez Martín, E., Calero Acuña, C. y López-Campos Bodineau, J.L. (2021). Predictors of single bronchodilation treatment response for copd: an observational study with the trace database cohort. Journal of Clinical Medicine, 10 (8)
dc.identifier.issn2077-0383es
dc.identifier.urihttps://hdl.handle.net/11441/125606
dc.description.abstractChronic obstructive pulmonary disease (COPD) patients constitute a heterogeneous population in terms of treatment response. Our objective was to identify possible predictive factors of response to treatment with single bronchodilation monotherapy in patients diagnosed with COPD. The Time-based Register and Analysis of COPD Endpoints (TRACE; clinicaltrials.gov NCT03485690) is a prospective cohort of COPD patients who have been attending annual visits since 2012. Patients who were kept on a single bronchodilator during the first year of follow-up were selected. The responders were defined according to all of the following variables: any improvement in morning post-dose forced expiratory volume in 1 s or deterioration <100 mL, no change or improvement in dyspnea score, and no occurrence of exacerbations. Significant and plausible variables were analyzed using a proportional hazard Cox regression for single bronchodilator responders. We analyzed 764 cases, of whom 128 (16.8%) were receiving monotherapy with one bronchodilator. Of these, 85 patients (66.4%) were responders. Factors affecting responder status were: female gender (hazard ratio (HR) 0.276; 95% confidence interval (CI) 0.089–0.858), dyslipidemia (HR 0.436; 95%CI 0.202–0.939), not performing regular exercise (HR 0.523; 95%CI 0.254–1.076), active smoking (HR 0.413; 95%CI 0.186–0.920), and treatment adherence (HR 2.527; 95%CI 1.271–5.027). The factors associated with a single bronchodilation response are mainly non-pharmacological interventions and comorbidities.es
dc.description.sponsorshipGebro Pharmaes
dc.formatapplication/pdfes
dc.format.extent8 p.es
dc.language.isoenges
dc.publisherMDPIes
dc.relation.ispartofJournal of Clinical Medicine, 10 (8)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCOPDes
dc.subjectLong-acting bronchodilatorses
dc.subjectClinical responsees
dc.subjectPharmacologicales
dc.titlePredictors of single bronchodilation treatment response for copd: an observational study with the trace database cohortes
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Medicinaes
dc.relation.publisherversionhttps://www.mdpi.com/2077-0383/10/8/1708es
dc.identifier.doi10.3390/jcm10081708es
dc.journaltitleJournal of Clinical Medicinees
dc.publication.volumen10es
dc.publication.issue8es

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