Predictors of single bronchodilation treatment response for copd: an observational study with the trace database cohort
|Author||Carrasco Hernández, Laura
Caballero Eraso, Candela
Ruiz Duque, Borja
Abad Arranz, María
Márquez Martín, Eduardo
Calero Acuña, Carmen
López-Campos Bodineau, José Luis
|Department||Universidad de Sevilla. Departamento de Medicina|
|Published in||Journal of Clinical Medicine, 10 (8)|
|Abstract||Chronic obstructive pulmonary disease (COPD) patients constitute a heterogeneous population in terms of treatment response. Our objective was to identify possible predictive factors of response to treatment with single ...
Chronic obstructive pulmonary disease (COPD) patients constitute a heterogeneous population in terms of treatment response. Our objective was to identify possible predictive factors of response to treatment with single bronchodilation monotherapy in patients diagnosed with COPD. The Time-based Register and Analysis of COPD Endpoints (TRACE; clinicaltrials.gov NCT03485690) is a prospective cohort of COPD patients who have been attending annual visits since 2012. Patients who were kept on a single bronchodilator during the first year of follow-up were selected. The responders were defined according to all of the following variables: any improvement in morning post-dose forced expiratory volume in 1 s or deterioration <100 mL, no change or improvement in dyspnea score, and no occurrence of exacerbations. Significant and plausible variables were analyzed using a proportional hazard Cox regression for single bronchodilator responders. We analyzed 764 cases, of whom 128 (16.8%) were receiving monotherapy with one bronchodilator. Of these, 85 patients (66.4%) were responders. Factors affecting responder status were: female gender (hazard ratio (HR) 0.276; 95% confidence interval (CI) 0.089–0.858), dyslipidemia (HR 0.436; 95%CI 0.202–0.939), not performing regular exercise (HR 0.523; 95%CI 0.254–1.076), active smoking (HR 0.413; 95%CI 0.186–0.920), and treatment adherence (HR 2.527; 95%CI 1.271–5.027). The factors associated with a single bronchodilation response are mainly non-pharmacological interventions and comorbidities.
|Citation||Carrasco Hernández, L., Caballero Eraso, C., Ruiz Duque, B., Abad Arranz, M., Márquez Martín, E., Calero Acuña, C. y López-Campos Bodineau, J.L. (2021). Predictors of single bronchodilation treatment response for copd: an observational study with the trace database cohort. Journal of Clinical Medicine, 10 (8)|