dc.creator | Álvarez-Sánchez, Nuria | es |
dc.creator | Cruz-Chamorro, Ivan | es |
dc.creator | Díaz Sánchez, María | es |
dc.creator | Lardone, Patricia Judith | es |
dc.creator | Guerrero Montávez, Juan Miguel | es |
dc.creator | Carrillo Vico, Antonio | es |
dc.date.accessioned | 2021-08-30T11:21:59Z | |
dc.date.available | 2021-08-30T11:21:59Z | |
dc.date.issued | 2019-02-19 | |
dc.identifier.citation | Álvarez-Sánchez, N., Cruz-Chamorro, I., Díaz Sánchez, M., Lardone, P.J., Guerrero Montávez, J.M. y Carrillo Vico, A. (2019). Peripheral CD39-expressing T regulatory cells are increased and associated with relapsing-remitting multiple sclerosis in relapsing patients. Scientific Reports, 9 (1), art.n.2302. https://doi.org/10.1038/s41598-019-38897-w. | |
dc.identifier.issn | 2045-2322 (electrónica) | es |
dc.identifier.uri | https://hdl.handle.net/11441/125216 | |
dc.description.abstract | CD39, an ectonucleotidase that hydrolyses pro-infammatory ATP, is a marker of highly active and
suppressive T regulatory cells (Tregs). Although CD39 has a role in Treg suppression and might be
important in the control of neuroinfammation in relapsing-remitting multiple sclerosis (RR-MS), to
date, there are contradictory reports concerning the Tregs expression of CD39 in RR-MS patients. Thus,
our objectives were to assess the activity and expression of CD39, especially in Tregs from peripheral
blood mononuclear cells (PBMCs) of relapsing RR-MS patients compared with control subjects and
to evaluate the association of CD39+ Tregs with disability and the odds of RR-MS. The activity and
expression of CD39 and the CD39+ Treg frequency were measured in PBMCs from 55 relapsing RR-MS
patients (19 untreated and 36 receiving immunomodulatory treatment) and 55 age- and sex-paired
controls. Moreover, the association between CD39+ Tregs and RR-MS was assessed by multivariate
logistic regression. CD39 activity and the frequency of CD39-expressing Tregs were elevated in relapsing
RR-MS patients. Moreover, CD39+ Tregs were signifcantly correlated with the EDSS score and were
independently associated with the odds of RR-MS. Our results highlight the relevance of CD39+ Treg
subset in the clinical outcomes of RR-MS. | es |
dc.description.sponsorship | Andalusian Government Ministry of Health (PI-0209-2010 PI-0485-2014, PC0019-2017) | es |
dc.description.sponsorship | PAIDI Program from the Andalusian Government (CTS160) | es |
dc.description.sponsorship | National Net RETICEF for Aging Studies | es |
dc.description.sponsorship | Red Temática de Investigación Cooperativa en Envejecimiento y Fragilidad | es |
dc.description.sponsorship | RD12/0043/0012 from the Instituto de Salud Carlos III | es |
dc.description.sponsorship | Spanish Ministerio de Ciencia e Innovación | es |
dc.description.sponsorship | Spanish Ministerio de Educación, Cultura y Deporte (FPU13/01210) | es |
dc.format | application/pdf | es |
dc.format.extent | 8 p. | es |
dc.language.iso | eng | es |
dc.publisher | Nature Research | es |
dc.relation.ispartof | Scientific Reports, 9 (1), art.n.2302. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | CD39 | es |
dc.subject | Multiple sclerosis | es |
dc.subject | T regulatory cells | es |
dc.subject | Tregs | es |
dc.title | Peripheral CD39-expressing T regulatory cells are increased and associated with relapsing-remitting multiple sclerosis in relapsing patients | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.relation.projectID | PI-0209-2010 | es |
dc.relation.projectID | PI-0485-2014 | es |
dc.relation.projectID | PC0019-2017 | es |
dc.relation.projectID | CTS160 | es |
dc.relation.projectID | RD12/0043/0012 | es |
dc.relation.projectID | FPU13/01210 | es |
dc.relation.publisherversion | https://www.nature.com/articles/s41598-019-38897-w | es |
dc.identifier.doi | 10.1038/s41598-019-38897-w | es |
dc.journaltitle | Scientific Reports | es |
dc.publication.volumen | 9 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | art.n.2302 | es |
dc.description.awardwinning | | |
dc.description.awardwinning | Premio Mensual Publicación Científica Destacada de la US. Facultad de Medicina | |