Peripheral CD39-expressing T regulatory cells are increased and associated with relapsing-remitting multiple sclerosis in relapsing patients
Díaz Sánchez, María
Lardone, Patricia Judith
Guerrero Montávez, Juan Miguel
Carrillo Vico, Antonio
|Department||Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología|
|Abstract||CD39, an ectonucleotidase that hydrolyses pro-infammatory ATP, is a marker of highly active and
suppressive T regulatory cells (Tregs). Although CD39 has a role in Treg suppression and might be
important in the control ...
CD39, an ectonucleotidase that hydrolyses pro-infammatory ATP, is a marker of highly active and suppressive T regulatory cells (Tregs). Although CD39 has a role in Treg suppression and might be important in the control of neuroinfammation in relapsing-remitting multiple sclerosis (RR-MS), to date, there are contradictory reports concerning the Tregs expression of CD39 in RR-MS patients. Thus, our objectives were to assess the activity and expression of CD39, especially in Tregs from peripheral blood mononuclear cells (PBMCs) of relapsing RR-MS patients compared with control subjects and to evaluate the association of CD39+ Tregs with disability and the odds of RR-MS. The activity and expression of CD39 and the CD39+ Treg frequency were measured in PBMCs from 55 relapsing RR-MS patients (19 untreated and 36 receiving immunomodulatory treatment) and 55 age- and sex-paired controls. Moreover, the association between CD39+ Tregs and RR-MS was assessed by multivariate logistic regression. CD39 activity and the frequency of CD39-expressing Tregs were elevated in relapsing RR-MS patients. Moreover, CD39+ Tregs were signifcantly correlated with the EDSS score and were independently associated with the odds of RR-MS. Our results highlight the relevance of CD39+ Treg subset in the clinical outcomes of RR-MS.
|Citation||Álvarez-Sánchez, N., Cruz-Chamorro, I., Díaz Sánchez, M., Lardone, P.J., Guerrero Montávez, J.M. y Carrillo Vico, A. (2019). Peripheral CD39-expressing T regulatory cells are increased and associated with relapsing-remitting multiple sclerosis in relapsing patients. Scientific Reports, 9 (1), art.n.2302.|
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