dc.creator | Gao Chen, Lin | es |
dc.creator | Ortega Sáenz, Patricia | es |
dc.creator | García Fernández, María | es |
dc.creator | González Rodríguez, Patricia | es |
dc.creator | Caballero Eraso, Candela | es |
dc.creator | López Barneo, José | es |
dc.date.accessioned | 2021-08-23T10:14:48Z | |
dc.date.available | 2021-08-23T10:14:48Z | |
dc.date.issued | 2014-10-15 | |
dc.identifier.citation | Gao Chen, L., Ortega Sáenz, P., García Fernández, M., González Rodríguez, P., Caballero Eraso, C. y López Barneo, J. (2014). Glucose sensing by carotid body glomus cells: potential implications in disease. Frontiers in Physiology, 5, art.n.398. | |
dc.identifier.issn | 1664-042X (electrónico) | es |
dc.identifier.uri | https://hdl.handle.net/11441/125141 | |
dc.description.abstract | The carotid body (CB) is a key chemoreceptor organ in which glomus cells sense changes
in blood O2, CO2, and pH levels. CB glomus cells have also been found to detect
hypoglycemia in both non-primate mammals and humans. O2 and low-glucose responses
share a common final pathway involving membrane depolarization, extracellular calcium
influx, increase in cytosolic calcium concentration, and neurotransmitter secretion, which
stimulates afferent sensory fibers to evoke sympathoadrenal activation. On the other
hand, hypoxia and low glucose induce separate signal transduction pathways. Unlike O2
sensing, the response of the CB to low glucose is not altered by rotenone, with the low
glucose-activated background cationic current unaffected by hypoxia. Responses of the
CB to hypoglycemia and hypoxia can be potentiated by each other. The counter-regulatory
response to hypoglycemia by the CB is essential for the brain, an organ that is particularly
sensitive to low glucose. CB glucose sensing could be altered in diabetic patients,
particularly those under insulin treatment, as well as in other medical conditions such as
sleep apnea or obstructive pulmonary diseases, where chronic hypoxemia presents with
plastic modifications in CB structure and function. The current review will focus on the
following main aspects: (1) the CB as a low glucose sensor in both in vitro and in vivo
models; (2) molecular and ionic mechanisms of low glucose sensing by glomus cells, (3)
the interplay between low glucose and O2 sensing in CB, and (4) the role of CB low
glucose sensing in the pathophysiology of cardiorespiratory and metabolic diseases, and
how this may serve as a potential therapeutic target. | es |
dc.description.sponsorship | Botín Foundation and the Spanish Ministry of Economy and Innovation (SAF program) | es |
dc.format | application/pdf | es |
dc.format.extent | 9 p. | es |
dc.language.iso | eng | es |
dc.publisher | Frontiers Media | es |
dc.relation.ispartof | Frontiers in Physiology, 5, art.n.398. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Carotid body | es |
dc.subject | Glucose sensing | es |
dc.subject | O2 sensing | es |
dc.subject | Hypoglycemia | es |
dc.subject | Intermittent hypoxia | es |
dc.subject | Sleep apnea | es |
dc.subject | Chronic hypoxia | es |
dc.subject | Diabetes | es |
dc.title | Glucose sensing by carotid body glomus cells: potential implications in disease | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fphys.2014.00398/full | es |
dc.identifier.doi | 0.3389/fphys.2014.00398 | es |
dc.journaltitle | Frontiers in Physiology | es |
dc.publication.volumen | 5 | es |
dc.publication.initialPage | art.n.398 | es |