dc.creator | Rabaneda, Luis G. | es |
dc.creator | Robles Lanuza, Estefanía | es |
dc.creator | Nieto González, José Luis | es |
dc.creator | Gómez Scholl, Francisco Manuel | es |
dc.date.accessioned | 2021-07-07T09:28:55Z | |
dc.date.available | 2021-07-07T09:28:55Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Rabaneda, L.G., Robles Lanuza, E., Nieto González, J.L. y Gómez Scholl, F.M. (2014). Neurexin Dysfunction in Adult Neurons Results in Autistic-like Behavior in Mice. Cell Reports, 8 (2), 338-346. | |
dc.identifier.issn | 2211-1247 | es |
dc.identifier.uri | https://hdl.handle.net/11441/115304 | |
dc.description.abstract | Autism spectrum disorders (ASDs) comprise a group of clinical phenotypes characterized by repetitive behavior and social and communication deficits.
Autism is generally viewed as a neurodevelopmental disorder where insults during embryonic or early postnatal periods result in aberrant wiring and function of neuronal circuits. Neurexins are synaptic proteins associated with autism. Here, we generated
transgenic bNrx1DC mice in which neurexin function is selectively impaired during late postnatal stages.
Whole-cell recordings in cortical neurons show an impairment of glutamatergic synaptic transmission in the bNrx1DC mice. Importantly, mutant mice exhibit autism-related symptoms, such as increased self-grooming, deficits in social interactions, and
altered interaction for nonsocial olfactory cues. The autistic-like phenotype of bNrx1DC mice can be reversed after removing the mutant protein in aged animals. The defects resulting from disruption of neurexin function after the completion of embryonic and early postnatal development suggest that functional impairment of mature circuits can trigger
autism-related phenotypes. | es |
dc.description.sponsorship | Instituto de Salud Carlos III (PI111058) | es |
dc.description.sponsorship | Junta de Andalucía (P11-CVI-7599) | es |
dc.description.sponsorship | NEURONERANET (EUHF-AUTISM, PIM2010ERN-0070) | es |
dc.format | application/pdf | es |
dc.format.extent | 9 | es |
dc.language.iso | eng | es |
dc.publisher | Cell Press | es |
dc.relation.ispartof | Cell Reports, 8 (2), 338-346. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Autism spectrum disorders (ASDs) | es |
dc.subject | Neurodevelopmental disorder | es |
dc.subject | Neurexin Dysfunction | es |
dc.title | Neurexin Dysfunction in Adult Neurons Results in Autistic-like Behavior in Mice | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.identifier.doi | 10.1016/j.celrep.2014.06.022 | es |
dc.contributor.group | Universidad de Sevilla. CTS1033: Sinaptopatías y Neurogenética | es |
dc.contributor.group | Universidad de Sevilla. CTS600: Fisiología Molecular de la Sinapsis | es |
dc.journaltitle | Cell Reports | es |
dc.publication.volumen | 8 | es |
dc.publication.issue | 2 | es |
dc.publication.initialPage | 338 | es |
dc.publication.endPage | 346 | es |
dc.contributor.funder | NEURONERANET (EUHF-AUTISM, PIM2010ERN-0070) | es |