dc.creator | Corchado, Sara | es |
dc.creator | López Cortés, Luis Fernando | es |
dc.creator | Rivero-Juárez, Antonio | es |
dc.creator | Torres Cornejo, Almudena | es |
dc.creator | Rivero, Antonio | es |
dc.creator | Márquez-Coello, Mercedes | es |
dc.creator | Girón-González, José-Antonio | es |
dc.date.accessioned | 2021-07-05T14:14:27Z | |
dc.date.available | 2021-07-05T14:14:27Z | |
dc.date.issued | 2014-07-11 | |
dc.identifier.citation | Corchado, S., López Cortés, L.F., Rivero-Juarez, A., Torres Cornejo, A., Rivero, A., Márquez-Coello, M. y Girón-González, J. (2014). Liver Fibrosis, Host Genetic and Hepatitis C Virus Related Parameters as Predictive Factors of Response to Therapy against Hepatitis C Virus in HIV/HCV Coinfected Patients. PLoS ONE, 9 (7), art. n.101760. | |
dc.identifier.issn | 1932-6203 (electrónico) | es |
dc.identifier.uri | https://hdl.handle.net/11441/115172 | |
dc.description.abstract | Objective: To establish the role of liver fibrosis as a predictive tool of response to pegylated interferon alpha (Peg-IFN) and
ribavirin (RBV) treatment in human immunodeficiency (HIV)/hepatitis C virus (HCV) coinfected patients, in addition to
recognized predictive factors (HCV load, HCV genotype, IL-28B polymorphism).
Patients and Methods: A sample of 267 HIV/HCV coinfected patients was treated with Peg-IFN and RBV. Predictive factors
of rapid (RVR) and sustained (SVR) virological response were analyzed. Independent variables were age, sex, IL28B, 2238
TNF-a and 2592 IL-10 polymorphisms, HCV genotype, HCV-RNA levels, significant fibrosis or cirrhosis and CD4+ T cell count.
Results: Patients infected by HCV genotype 1 (n = 187) showed RVR and SVR in 12% and 39% of cases, respectively. The
parameters associated with RVR were IL28B genotype CC and plasma HCV-RNA levels ,600000 IU/ml. Advanced liver
fibrosis was negatively associated with SVR in patients without RVR. A SVR was obtained in 42% of subjects with HCV
genotype 4, and the independent factors associated with SVR were IL28B genotype CC and an HCV-RNA ,600000 IU/ml. A
SVR was obtained in 66% of patients with HCV genotypes 2/3; in this case, the independent parameter associated with SVR
was the absence of significant liver fibrosis. TNF-a and IL-10 polymorphisms were not associated with SVR, although a
significantly higher percentage of 2238 TNF-a genotype GG was detected in patients with significant liver fibrosis.
Conclusions: In HIV/HCV coinfected patients with HCV genotypes 1 or 4, RVR, mainly influenced by genotype IL28B and
HCV-RNA levels, reliably predicted SVR after 4 weeks of therapy with Peg-IFN plus RBV. In patients infected by HCV
genotype 3, an elevated relapse rate compromised the influence of RVR on SVR. Relapses were related to the presence of
advanced liver fibrosis. Liver cirrhosis was associated with a 2238 TNF-a polymorphism in these patients. | es |
dc.description.sponsorship | Consejería de Salud, Junta de Andalucía (PI-0076/2008, PI-0157/2011 and PI-0430/2012) | es |
dc.description.sponsorship | Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III (PI 08/0869 and PI11/00605) | es |
dc.description.sponsorship | Instituto de Salud Carlos III | es |
dc.format | application/pdf | es |
dc.format.extent | 10 p. | es |
dc.language.iso | eng | es |
dc.publisher | Public Library of Science | es |
dc.relation.ispartof | PLoS ONE, 9 (7), art. n.101760. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Liver Fibrosis | es |
dc.subject | Hepatitis C | es |
dc.subject | HIV/HCV | es |
dc.title | Liver Fibrosis, Host Genetic and Hepatitis C Virus Related Parameters as Predictive Factors of Response to Therapy against Hepatitis C Virus in HIV/HCV Coinfected Patients | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.projectID | PI-0076/2008 | es |
dc.relation.projectID | PI-0157/2011 | es |
dc.relation.projectID | PI-0430/2012 | es |
dc.relation.projectID | PI 08/0869 | es |
dc.relation.projectID | PI11/00605 | es |
dc.relation.publisherversion | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101760 | es |
dc.identifier.doi | 10.1371/journal.pone.0101760 | es |
dc.journaltitle | PLoS ONE | es |
dc.publication.volumen | 9 | es |
dc.publication.issue | 7 | es |
dc.publication.initialPage | art. n.101760 | es |