dc.creator | Lavado-Roldán, Ángela | es |
dc.creator | Fernández-Chacón, Rafael | es |
dc.date.accessioned | 2021-06-29T16:28:40Z | |
dc.date.available | 2021-06-29T16:28:40Z | |
dc.date.issued | 2016-07-25 | |
dc.identifier.citation | Lavado-Roldán, Á. y Fernández-Chacón, R. (2016). Two for the Price of One: A Neuroprotective Chaperone Kit within NAD Synthase Protein NMNAT2. Plos Biology, 14 (7), art. n.1002522. | |
dc.identifier.issn | 1544-9173 (impreso) | es |
dc.identifier.issn | 1545-7885 (electrónico) | es |
dc.identifier.uri | https://hdl.handle.net/11441/114942 | |
dc.description.abstract | One of the most fascinating properties of the brain is the ability to function smoothly across
decades of a lifespan. Neurons are nondividing mature cells specialized in fast electrical
and chemical communication at synapses. Often, neurons and synapses operate at high
levels of activity through sophisticated arborizations of long axons and dendrites that nevertheless stay healthy throughout years. On the other hand, aging and activity-dependent
stress strike onto the protein machineries turning proteins unfolded and prone to form pathological aggregates associated with neurodegeneration. How do neurons protect from
those insults and remain healthy for their whole life? Ali and colleagues now present a
molecular mechanism by which the enzyme nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) acts not only as a NAD synthase involved in axonal maintenance but as a
molecular chaperone helping neurons to overcome protein unfolding and protein
aggregation. | es |
dc.description.sponsorship | Spanish Ministerio de Economía y Competititividad (MINECO) (BFU2013-47493) | es |
dc.description.sponsorship | Junta de Andalucía (P12-CTS-2232) | es |
dc.description.sponsorship | Instituto de Salud Carlos III and Fondo Europeo de Desarrollo Regional | es |
dc.description.sponsorship | MINECO (BES-2011-046029) | es |
dc.format | application/pdf | es |
dc.format.extent | 5 p. | es |
dc.language.iso | eng | es |
dc.publisher | Public Library of Science | es |
dc.relation.ispartof | Plos Biology, 14 (7), art. n.1002522. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Enzyme nicotinamide mononucleotide adenylyltransferase 2 | es |
dc.subject | NMNAT2 | es |
dc.subject | Brain | es |
dc.subject | Neurons | es |
dc.subject | NAD synthase | es |
dc.title | Two for the Price of One: A Neuroprotective Chaperone Kit within NAD Synthase Protein NMNAT2 | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.relation.projectID | BFU2013-47493 | es |
dc.relation.projectID | P12-CTS-2232 | es |
dc.relation.projectID | BES-2011-046029 | es |
dc.relation.publisherversion | https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002522 | es |
dc.identifier.doi | 10.1371/ journal.pbio.1002522 | es |
dc.journaltitle | Plos Biology | es |
dc.publication.volumen | 14 | es |
dc.publication.issue | 7 | es |
dc.publication.initialPage | art. n.1002522 | es |