dc.creator | Fernández, Raquel María | es |
dc.creator | Peciña, Ana | es |
dc.creator | Lozano Arana, María Dolores | es |
dc.creator | Sánchez, Beatriz | es |
dc.creator | Guardiola, Jordi | es |
dc.creator | García-Lozano, Juan Carlos | es |
dc.creator | Antiñolo Gil, Guillermo | es |
dc.date.accessioned | 2021-06-07T18:08:34Z | |
dc.date.available | 2021-06-07T18:08:34Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Fernández, R.M., Peciña, A., Lozano Arana, M.D., Sánchez, B., Guardiola, J., García-Lozano, J.C. y Antiñolo Gil, G. (2014). Experience of Preimplantation Genetic Diagnosis with HLA Matching at the University Hospital Virgen del Rocío in Spain: Technical and Clinical Overview. BioMed Research International, 2014, art. n.560160-. | |
dc.identifier.issn | 2314-6141 (electrónico) | es |
dc.identifier.uri | https://hdl.handle.net/11441/111473 | |
dc.description.abstract | Preimplantation genetic diagnosis (PGD) of genetic diseases, combined with HLA matching (PGD-HLA), is an option for couples
at risk of transmitting a genetic disease to select unaffected embryos of an HLA tissue type compatible with that of an existing
affected child. Here we present the results of our PGD-HLA program at the Department of Genetics, Reproduction and Fetal
Medicine of the University Hospital Virgen del Roc´ıo in Seville. Seven couples have participated in our program because of different
indications. Overall, 26 cycles were performed, providing a total of 202 embryos. A conclusive molecular diagnosis and HLA-typing
could be assured in 96% of the embryos. The percentage of transfers per cycle was 26.9% and the birth rate per cycle was 7.7% per
transfer. Our PGD-HLA program resulted in the birth of 2 healthy babies, HLA-identical to their affected siblings, with successful
subsequent haematopoietic stem cell (HSC) transplantations. Both HSC-transplanted children are currently doing well 48 and 21
months following transplantation, respectively. All the procedures, including HSCs umbilical cord transplantation, were performed
in our hospital. | es |
dc.format | application/pdf | es |
dc.format.extent | 8 | es |
dc.language.iso | eng | es |
dc.publisher | Hindawi | es |
dc.relation.ispartof | BioMed Research International, 2014, art. n.560160-. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Preimplantation Genetic Diagnosis | es |
dc.subject | HLA Matching | es |
dc.subject | University Hospital Virgen del Rocío | es |
dc.title | Experience of Preimplantation Genetic Diagnosis with HLA Matching at the University Hospital Virgen del Rocío in Spain: Technical and Clinical Overview | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Cirugía | es |
dc.relation.publisherversion | https://www.hindawi.com/journals/bmri/2014/560160/ | es |
dc.identifier.doi | 10.1155/2014/560160 | es |
dc.journaltitle | BioMed Research International | es |
dc.publication.volumen | 2014 | es |
dc.publication.initialPage | art. n.560160 | es |