Artículo
Experience of Preimplantation Genetic Diagnosis with HLA Matching at the University Hospital Virgen del Rocío in Spain: Technical and Clinical Overview
Autor/es | Fernández, Raquel María
Peciña, Ana Lozano Arana, María Dolores Sánchez, Beatriz Guardiola, Jordi García-Lozano, Juan Carlos Antiñolo Gil, Guillermo |
Departamento | Universidad de Sevilla. Departamento de Cirugía |
Fecha de publicación | 2014 |
Fecha de depósito | 2021-06-07 |
Publicado en |
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Resumen | Preimplantation genetic diagnosis (PGD) of genetic diseases, combined with HLA matching (PGD-HLA), is an option for couples
at risk of transmitting a genetic disease to select unaffected embryos of an HLA tissue type ... Preimplantation genetic diagnosis (PGD) of genetic diseases, combined with HLA matching (PGD-HLA), is an option for couples at risk of transmitting a genetic disease to select unaffected embryos of an HLA tissue type compatible with that of an existing affected child. Here we present the results of our PGD-HLA program at the Department of Genetics, Reproduction and Fetal Medicine of the University Hospital Virgen del Roc´ıo in Seville. Seven couples have participated in our program because of different indications. Overall, 26 cycles were performed, providing a total of 202 embryos. A conclusive molecular diagnosis and HLA-typing could be assured in 96% of the embryos. The percentage of transfers per cycle was 26.9% and the birth rate per cycle was 7.7% per transfer. Our PGD-HLA program resulted in the birth of 2 healthy babies, HLA-identical to their affected siblings, with successful subsequent haematopoietic stem cell (HSC) transplantations. Both HSC-transplanted children are currently doing well 48 and 21 months following transplantation, respectively. All the procedures, including HSCs umbilical cord transplantation, were performed in our hospital. |
Cita | Fernández, R.M., Peciña, A., Lozano Arana, M.D., Sánchez, B., Guardiola, J., García-Lozano, J.C. y Antiñolo Gil, G. (2014). Experience of Preimplantation Genetic Diagnosis with HLA Matching at the University Hospital Virgen del Rocío in Spain: Technical and Clinical Overview. BioMed Research International, 2014, art. n.560160-. |
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