Envíos recientes

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    EUropean prospective cohort study on Enterobacteriaceae showing REsistance to CArbapenems (EURECA): a protocol of a European multicentre observational study  [Artículo]

    Gutiérrez Gutiérrez, Belén.; Sojo Dorado, Jesús; Bravo Ferrer, José; Rodriguez Baño, Jesus (2017-02-07)
    Introduction: The rapid worldwide spread of carbapenem-resistant Enterobacteriaceae (CRE) constitutes a major challenge. The aim of the EUropean prospective cohort study on Enterobacteriaceae showing REsistance to ...
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    C-MYB- and PGC1a-dependent metabolic switch induced by MYBBP1A loss in renal cancer  [Artículo]

    Felipe Abrio, Blanca; Verdugo Sivianes, Eva María; Carnero, Amancio (FEBS Press and John Wiley & Sons Ltd., 2019-05-07)
    Our work reveals that MYBBP1A downregulation simultaneously activates PGC1α directly by alleviating direct repression and indirectly by increasing the PGC1α levels through c-MYB. By PGC1α activation, cellular metabolism ...
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    AIP and MEN1 mutations and AIP immunohistochemistry in pituitary adenomas in a tertiary referral center.  [Artículo]

    Cano González, David A.; Venegas Moreno, Eva; Flores Martínez, Álvaro (2019)
    Background: Pituitary adenomas have a high disease burden due to tumor growth/ invasion and disordered hormonal secretion. Germline mutations in genes such as MEN1 and AIP are associated with early onset of aggressive ...
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    Biomarkers predictive value for early diagnosis of Stroke- Associated Pneumonia.  [Artículo]

    Zapata Arriaza, Elena; Mancha Molina, Fernando; Moniche Álvarez, Francisco; Pardo Galiana, Blanca; Vega Salvatierra, Ángela; Ramos Herrero, Víctor Darío; Montaner Villalonga, Joan (2019-06-25)
    To confirm the diagnostic accuracy of candidate biomarkers in stroke-associ- ated pneumonia (SAP), we prospectively enrolled ischemic stroke patients with NIHSS ≥ 10 on admission from March-2016 to August-2017. Blood ...
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    Research highlights from the 2018 European Respiratory Society International Congress: Airway disease  [Artículo]

    Schleich, Florence; Bikov, Andras; Mathioudakis, Alexander G.; McDonnell, Melissa; Andersson, Cecilia; Bonini, Matteo; Uller, Lena; Idzko, Marco; Singh, Dave; López Campos, José Luis (European Respiratory Society, 2010)
    The annual European Respiratory Society (ERS) International Congress (held in Paris in 2018) was once again a platform for discussion of the highest-quality scientific research, cutting-edge techniques and innovative new ...
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    Epigenetic Mechanisms in Hirschsprung Disease  [Artículo]

    Torroglosa, Ana; Villalba Benito, Leticia; Luzón-Toro, Berta; Fernández García, Raquel María; Antiñolo Gil, Guillermo; Borrego López, Salud (MDPI, 2019-06-26)
    Hirschsprung disease (HSCR, OMIM 142623) is due to a failure of enteric precursor cells derived from neural crest (EPCs) to proliferate, migrate, survive or differentiate during Enteric Nervous System (ENS) formation. This ...
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    Redox-dependent and redox-independent functions of Caenorhabditis elegans thioredoxin 1  [Artículo]

    Sanzo-Machuca, Ángela; Monje Moreno, José Manuel; Casado-Navarro, Rafael; Karakuzu, Ozgur; Guerrero Gómez, David; Fierro-González, Juan Carlos; Swoboda, Peter; Muñoz, Manuel J.; Miranda Vizuete, Antonio (Elsevier, 2019-06)
    Thioredoxins (TRX) are traditionally considered as enzymes catalyzing redox reactions. However, redox-independent functions of thioredoxins have been described in different organisms, although the underlying molecular ...
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    FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I–induced DNA breakage and transcriptional stress  [Artículo]

    Martínez Macías, María Isabel; Green, Ryan L.; Gómez Herreros, Fernando; Naumann, Marcel; Hermann, Andreas; Hafezparast, Majid; Caldecott, Keith W.; Moore, Duncan A. Q.; Damme, Philip Van (Rockefeller University Press, 2019-02-26)
    FUS (fused in sarcoma) plays a key role in several steps of RNA metabolism, and dominant mutations in this protein are associated with neurodegenerative diseases. Here, we show that FUS is a component of the cellular ...
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    Late-onset thymidine kinase 2 deficiency: a review of 18 cases  [Artículo]

    Domínguez González, Cristina; Hernández Laín, Aurelio; Rivas, Eloy; Hernández Voth, Ana R.; Sayas Catalán, Javier; Fernández Torrón, Roberto; Fuiza Luces, Carmen; García García, Jorge M.; Caballero Eraso, Candelaria; Paradas, Carmen (Springer Nature, 2019-05-06)
    BACKGROUND: TK2 gene encodes for mitochondrial thymidine kinase, which phosphorylates the pyrimidine nucleosides thymidine and deoxycytidine. Recessive mutations in the TK2 gene are responsible for the 'myopathic form' of ...
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    FGFR1 Cooperates with EGFR in Lung Cancer Oncogenesis, and Their Combined Inhibition Shows Improved Efficacy  [Artículo]

    Quintanal Villalonga, Álvaro Diego; Molina Pinelo, Sonia; Cirauqui, Cristina; Ojeda Márquez, Laura; Marrugal, Ángela; Suárez, Rocío; Conde, Esther; Ponce Aix, Santiago; Enguita, Ana Belén; Ferrer, Irene; Paz Ares, Luis; Carnero Moya, Amancio (Elsevier, 2019-04)
    Introduction: There is substantial evidence for the onco- genic effects of fi broblast growth factor receptor 1 (FGFR1) in many types of cancer, including lung cancer, but the role of this receptor has not been ...
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    E-cadherin expression is associated with somatostatin analogue response in acromegaly  [Artículo]

    Venegas Moreno, Eva; Flores Martínez, Álvaro; Dios, Elena; Vázquez Borrego, Mari C.; Ibáñez Costa, Alejandro; Madrazo Atutxa, Ainara; Japón Rodríguez, Miguel Ángel; Castaño, Justo P.; Luque, Raúl M.; Cano, David A.; Soto Moreno, Alfonso Manuel (Wiley-Blackwell, 2019)
    Acromegaly is a rare disease resulting from hypersecretion of growth hormone (GH) and insulin‐like growth factor 1 (IGF1) typically caused by pituitary adenomas, which is associated with increased mortality and morbidity. ...
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    Immunometabolism is a key factor for the persistent spontaneous elite control of HIV-1 infection  [Artículo]

    Tarancon Diez, Laura; Rodríguez-Gallego, Laura; Rull, Anna; Peraire, Joaquim; Viladés, Consuelo; Portilla, Irene; Jiménez León, María Reyes; Alba, Verónica; Herrero, Pol; Leal Noval, Manuel; Ruiz Mateos Carmona, Ezequiel; Vidal, Francesc (Elsevier, 2019-03)
    Approximately 25% of elite controllers (ECs) lose their virological control by mechanisms that are only partially known. Recently, immunovirological and proteomic factors have been associated to the loss of spontaneous ...
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    Visualization of coronary arteries in paediatric patients using whole-heart coronary magnetic resonance angiography: comparison of image-navigation and the standard approach for respiratory motion compensation  [Artículo]

    Velasco Forte, Mari Nieves; Valverde, Israel; Prabhu, Nanda; Correia, Teresa; Narayan, Srinivas Ananth; Bell, Aaron; Mathur, Sujeev; Razavi, Reza; Hussain, Tarique; Pushparajah, Kuberan; Henningsson, Markus (Springer Nature, 2019-02)
    Aims: To investigate the use of respiratory motion compensation using image-based navigation (iNAV) with constant respiratory efficiency using single end-expiratory thresholding (CRUISE) for coronary magnetic resonance ...
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    Altered myogenesis and premature senescence underlie human TRIM32-related myopathy  [Artículo]

    Servián Morilla, Emilia; Cabrera Serrano, Macarena; Carvajal, A.; Lamont, P.J.; Pelayo Negro, A. L.; Ravenscroft, G.; Junckerstorff, R.; Dyke, J.M; Fletcher, S.; Adams, A. M.; Fernández García, M. A.; Nieto González, José Luis; Laing, N. G.; Rivas, Eloy; Mavillard Saborido, Fabiola; Paradas, Carmen (Springer Nature, 2019-03-01)
    TRIM32 is a E3 ubiquitin -ligase containing RING, B-box, coiled-coil and six C-terminal NHL domains. Mutations involving NHL and coiled-coil domains result in a pure myopathy (LGMD2H/STM) while the only described mutation ...
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    The impact of initial antibiotic treatment failure: Real-world insights in patients with complicated, health care-associated intra-abdominal infection  [Artículo]

    Peeters, Pascale; Ryan, Kellie; Karve, Sudeep; Potter, Danielle; Baelen, Elisa; Rojas-Farreras, Sonia; Rodríguez-Baño, Jesús (Dove, 2019-01-31)
    Purpose: The RECOMMEND study (NCT02364284; D4280R00005) assessed the clinical management patterns and treatment outcomes associated with initial antibiotic therapy (IAT; antibiotics administered ≤48 hours post-initiation ...
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    Protective Effects of Human and Mouse Soluble Scavenger-Like CD6 Lymphocyte Receptor in a Lethal Model of Polymicrobial Sepsis  [Artículo]

    Martínez-Florensa, Mario; Consuegra-Fernández, Marta; Aranda, Fernando; Armiger-Borràs, Noelia; Di Scala, Marianna; Carrasco, Esther; Pachón Díaz, Jerónimo; Vila, Jordi; González-Aseguinolaza, Gloria; Lozano, Francisco (American Society for Microbiology, 2017-11)
    Sepsis still constitutes an unmet clinical need, which could benefit from novel adjunctive strategies to conventional antibiotic therapy. The soluble form of the scavenger-like human CD6 lymphocyte receptor (shCD6) binds ...
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    Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology  [Artículo]

    Romero Molina, Carmen; Navarro Garrido, Victoria; Sánchez Varo, Raquel María; Jiménez Muñoz, Sebastián; Fernández Valenzuela, Juan José; Sánchez Mico, María; Muñoz Castro, Clara; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa (Frontiers Media Research Foundation, 2018-11-14)
    Microglial cells are crucial players in the pathological process of neurodegenerative diseases, such as Alzheimer’s disease (AD). Microglial response in AD has been principally studied in relation to amyloid-beta pathology ...
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    In vitro Activity of Pentamidine Alone and in Combination With Aminoglycosides, Tigecycline, Rifampicin, and Doripenem Against Clinical Strains of Carbapenemase-Producing and/or Colistin-Resistant Enterobacteriaceae  [Artículo]

    Cebrero Cangueiro, Tania; Álvarez Marín, Rocío; Labrador Herrera, Gema; Smani, Younes; Cordero Matia, María Elisa (Frontiers Media SA, 2018-10-18)
    Enterobacteriaceae cause different types of community- and hospital-acquired infections. Moreover, the spread of multidrug-resistant Enterobacteriaceae is a public health problem and the World Health Organization pointed ...
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    Association between sleep-disordered breathing and breast cancer aggressiveness  [Artículo]

    Campos-Rodríguez, Francisco; Cruz-Medina, Antonio; Selma, María José; Rodríguez-de-la-Borbolla-Artacho, María; Sanchez-Vega, Adrian; Ripoll-Orts, Francisco; Almeida González, Carmen V.; Martinez-Garcia, Miguel Angel (Public Library of Science, 2018-11-21)
    Background Sleep-disordered breathing (SDB) has been associated with cancer aggressiveness, but studies focused on specific tumors are lacking. In this pilot study we investigated whether SDB is associated with breast ...
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    Intestinal colonization due to Escherichia coli ST131: Risk factors and prevalence  [Artículo]

    Morales Barroso, Isabel; López Cerero, Lorena; Navarro, María Dolores; Gutiérrez Gutiérrez, Belén; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (Biomed Central, 2018-11-15)
    Background Escherichia coli sequence type 131 (ST131) is a successful clonal group that has dramatically spread during the last decades and is considered an important driver for the rapid increase of quinolone resistance ...

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