Artículos (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER)): Envíos recientes
Mostrando ítems 41-60 de 183
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MutSβ regulates G4-associated telomeric R-loops to maintain telomere integrity in ALT cancer cells
(Elsevier, 2022)Up to 15% of human cancers maintain their telomeres through a telomerase-independent mechanism, termed “alternative ...
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Homologous recombination and Mus81 promote replication completion in response to replication fork blockage
(Wiley-Blackwell, 2020)Impediments to DNA replication threaten genome stability. The homologous recombination (HR) pathway has been involved in ...
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Architecture and nucleic acids recognition mechanism of the THO complex, an mRNP assembly factor
(Wiley-Blackwell, 2012)The THO complex is a key factor in co-transcriptional formation of export-competent messenger ribonucleoprotein particles, ...
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XRCC1 Prevents Replication Fork Instability during Misincorporation of the DNA Demethylation Bases 5-Hydroxymethyl-2′-Deoxycytidine and 5-Hydroxymethyl-2′-Deoxyuridine
(MDPI, 2022)Whilst avoidance of chemical modifications of DNA bases is essential to maintain genome stability, during evolution ...
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VID22 counteracts G-quadruplex-induced genome instability
(Oxford University Press, 2021)Genome instability is a condition characterized by the accumulation of genetic alterations and is a hallmark of cancer ...
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Immune signaling kinases in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disorder of motor neurons in adults, with a median ...
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Distinct responses of human peripheral blood cells to different misfolded protein oligomers
(Wiley-Blackwell, 2021)Increasing evidence indicates that peripheral immune cells play a prominent role in neurodegeneration connected to protein ...
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Non-recombinogenic roles for Rad52 in translesion synthesis during DNA damage tolerance
(Wiley-Blackwell, 2021)DNA damage tolerance relies on homologous recombination (HR) and translesion synthesis (TLS) mechanisms to fill in the ...
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A CDK-regulated chromatin segregase promoting chromosome replication
(Springer Nature, 2021)The replication of chromosomes during S phase is critical for cellular and organismal function. Replicative stress can ...
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A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells
(Springer Nature, 2021)BRCA1 or BRCA2 germline mutations predispose to breast, ovarian and other cancers. High-throughput sequencing of tumour ...
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Harmful R-loops are prevented via different cell cycle-specific mechanisms
(Springer Nature, 2021)Identifying how R-loops are generated is crucial to know how transcription compromises genome integrity. We show by ...
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Dna-rna hybrids at dsbs interfere with repair by homologous recombination
(eLife Sciences Publications, 2021)DNA double-strand breaks (DSBs) are the most harmful DNA lesions and their repair is crucial for cell viability and genome ...
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White Button Mushroom Extracts Modulate Hepatic Fibrosis Progression, Inflammation, and Oxidative Stress In Vitro and in LDLR-/- Mice
(MDPI, 2021)Liver fibrosis can be caused by non-alcoholic steatohepatitis (NASH), among other conditions. We performed a study to ...
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Nuclear Envelope Integrity in Health and Disease: Consequences on Genome Instability and Inflammation
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)The dynamic nature of the nuclear envelope (NE) is often underestimated. The NE protects, regulates, and organizes the ...
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Thyroid hormones in diabetes, cancer, and aging
(Wiley, 2020)Thyroid function is central in the control of physiological and pathophysiological processes. Studies in animal models and ...
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Molecular modelling of islet β-cell adaptation to inflammation in pregnancy and gestational diabetes mellitus
(Multidisciplinary Digital Publishing Institute (MDPI), 2019)Gestational diabetes mellitus (GDM), a metabolic disease that develops with the increase in insulin resistance during late ...
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TDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands
(Wiley-Blackwell, 2020)Androgens stimulate the proliferation of epithelial cells in the prostate by activating topoisomerase 2 (TOP2) and regulating ...
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The antitumor drugs trabectedin and lurbinectedin induce transcription-dependent replication stress and genome instability
(American Association for Cancer Research, 2019)R-loops are a major source of replication stress, DNA damage, and genome instability, which are major hallmarks of cancer ...
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The need to regulate replication fork speed
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DNA-RNA hybrids: The risks of DNA breakage during transcription
(Springer Nature, 2017)Although R loops can occur at different genomic locations, the factors that determine their formation and frequency remain ...