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Artículo
MutSβ regulates G4-associated telomeric R-loops to maintain telomere integrity in ALT cancer cells
(Elsevier, 2022)
Up to 15% of human cancers maintain their telomeres through a telomerase-independent mechanism, termed “alternative lengthening of telomeres” (ALT) that relies on homologous recombination between telomeric sequences. ...
Artículo
Topoisomerase 1-dependent R-loop deficiency drives accelerated replication and genomic instability
(Elsevier, 2022)
DNA replication is a complex process tightly regulated to ensure faithful genome duplication, and its perturbation leads to DNA damage and genomic instability. Replication stress is commonly associated with slow and stalled ...