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Artículo
Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage
(Shared Science Publishers OG, 2020)
The stability and function of eukaryotic genomes is closely linked to histones and to chromatin structure. The state of the chromatin not only affects the probability of DNA to undergo damage but also DNA repair. DNA damage ...
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The DNA damage response acts as a safeguardagainst harmful DNA–RNA hybrids ofdifferent origins
(EMBO Press, 2019-07-24)
Despite playing physiological roles in specific situations, DNA–RNA hybrids threat genome integrity. To investigate how cells do counteract spontaneous DNA–RNA hybrids, here we screen an siRNA library covering 240 human ...
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The need to regulate replication fork speed
(American Association for the Advancement of Science, 2017)
Artículo
Transcription-mediated replication hindrance: a major driver of genome instability
(Cold Spring Harbor Laboratory Press, 2019)
Genome replication involves dealing with obstacles that can result from DNA damage but also from chromatin alterations, topological stress, tightly bound proteins or non-B DNA structures such as R loops. Experimental ...
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DNA-RNA hybrids: The risks of DNA breakage during transcription
(Springer Nature, 2017)
Although R loops can occur at different genomic locations, the factors that determine their formation and frequency remain unclear. Emerging evidence indicates that DNA breaks stimulate DNA-RNA hybrid formation. Here, we ...
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Histone deacetylases facilitate the accurate repair of broken forks
(Taylor & Francis, 2020)
We have recently uncovered that loss of the yeast histone deacetylases Rpd3 (Reduced Potassium Dependency 3) and Hda1 (Histone DeAcetylase 3) affects the cohesion between sister chromatids thus impairing repair of DNA ...
Artículo
Harmful DNA:RNA hybrids are formed in cis and in a Rad51-independent manner
(eLife Sciences Publications, 2020)
DNA:RNA hybrids constitute a well-known source of recombinogenic DNA damage. The current literature is in agreement with DNA:RNA hybrids being produced co-transcriptionally by the invasion of the nascent RNA molecule ...
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Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle
(Taylor & Francis, 2020)
A large body of research supports that transcription plays a major role among the many sources of replicative stress contributing to genome instability. It is therefore not surprising that the DNA damage response has a ...
Artículo
Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion
(Nature Research, 2019)
Genome stability involves accurate replication and DNA repair. Broken replication forks, such as those encountering a nick, lead to double strand breaks (DSBs), which are preferentially repaired by sister-chromatid ...
Artículo
Looping the (R) Loop in DSB Repair via RNA Methylation
(Elsevier, 2020)
In this issue of Molecular Cell, Zhang et al. (2020) reveal that ATM triggers RNA methylation of DNA-RNA hybrids formed at double-strand breaks (DSBs) to modulate repair, adding a new layer of complexity to RNA's role in ...