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Artículo
Break-induced RNA–DNA hybrids (BIRDHs) in homologous recombination: friend or foe?
(Wiley-Blackwell, 2023)
Double-strand breaks (DSBs) are the most harmful DNA lesions, with a strong impact on cell proliferation and genome integrity. Depending on cell cycle stage, DSBs are preferentially repaired by non-homologous end joining ...
Artículo
The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores
(Elsevier, 2011)
Transcription hinders replication fork progression and stability, and the Mec1/ATR checkpoint protects fork integrity. Examining checkpoint-dependent mechanisms controlling fork stability, we find that fork reversal and ...