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Artículo
Transcription as a Threat to Genome Integrity
(Annual Reviews Inc., 2016)
Genomes undergo different types of sporadic alterations, including DNA damage, point mutations, and genome rearrangements, that constitute the basis for evolution. However, these changes may occur at high levels as a result ...
Artículo
The Nup84 complex coordinates the DNA damage response to warrant genome integrity
(Oxford University Press, 2019)
DNA lesions interfere with cellular processes such as transcription and replication and need to be adequately resolved to warrant genome integrity. Beyond their primary role in molecule transport, nuclear pore complexes ...
Artículo
Gene gating at nuclear pores prevents the formation of R loops
(Taylor and Francis Ltd., 2018)
Transcription is an important source of genetic variability. A large amount of transcription-associated genome variation arises from the unscheduled formation of R loops. We have recently found that physical proximity of ...