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Artículo
Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage
(Shared Science Publishers OG, 2020)
The stability and function of eukaryotic genomes is closely linked to histones and to chromatin structure. The state of the chromatin not only affects the probability of DNA to undergo damage but also DNA repair. DNA damage ...
Artículo
Limiting glutamine utilization activates a GCN2/TRAIL-R2/Caspase-8 apoptotic pathway in glutamine-addicted tumor cells
(Springer Nature, 2022)
Oncogenic transformation leads to changes in glutamine metabolism that make transformed cells highly dependent on glutamine for anabolic growth and survival. Herein, we investigated the cell death mechanism activated in ...
Artículo
CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes
(Springer Nature, 2021)
Proper chromosome segregation is essential to avoid aneuploidy, yet this process fails with increasing age in mammalian oocytes. Here we report a role for the scarcely described protein CENP-V in oocyte spindle formation ...
Artículo
MutSβ regulates G4-associated telomeric R-loops to maintain telomere integrity in ALT cancer cells
(Elsevier, 2022)
Up to 15% of human cancers maintain their telomeres through a telomerase-independent mechanism, termed “alternative lengthening of telomeres” (ALT) that relies on homologous recombination between telomeric sequences. ...
Artículo
Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy
(Nature Research, 2024-01-17)
ATTR amyloidosis is caused by the deposition of transthyretin in the form of amyloid fibrils in virtually every organ of the body, including the heart. This systemic deposition leads to a phenotypic variability that has ...
Artículo
Break-induced RNA–DNA hybrids (BIRDHs) in homologous recombination: friend or foe?
(Wiley-Blackwell, 2023)
Double-strand breaks (DSBs) are the most harmful DNA lesions, with a strong impact on cell proliferation and genome integrity. Depending on cell cycle stage, DSBs are preferentially repaired by non-homologous end joining ...
Artículo
The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts
(Nature Research, 2023)
Genome instability is a feature of cancer cells, transcription being an important source of DNA damage. This is in large part associated with R-loops, which hamper replication, especially at head-on transcription-replication ...
Artículo
Non-recombinogenic roles for Rad52 in translesion synthesis during DNA damage tolerance
(Wiley-Blackwell, 2021)
DNA damage tolerance relies on homologous recombination (HR) and translesion synthesis (TLS) mechanisms to fill in the ssDNA gaps generated during passing of the replication fork over DNA lesions in the template. Whereas ...
Artículo
A CDK-regulated chromatin segregase promoting chromosome replication
(Springer Nature, 2021)
The replication of chromosomes during S phase is critical for cellular and organismal function. Replicative stress can result in genome instability, which is a major driver of cancer. Yet how chromatin is made accessible ...
Artículo
Nuclear Envelope Integrity in Health and Disease: Consequences on Genome Instability and Inflammation
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)
The dynamic nature of the nuclear envelope (NE) is often underestimated. The NE protects, regulates, and organizes the eukaryote genome and adapts to epigenetic changes and to its environment. The NE morphology is characterized ...