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Mostrando ítems 11-20 de 32
Artículo
SEOM clinical guidelines in advanced and recurrent breast cancer (2018)
(Springer, 2019)
Although the metastasic breast cancer is still an incurable disease, recent advances have increased signifcantly the time to progression and the overall survival. However, too much information has been produced in the ...
Artículo
Concordance between the Clinical Definition of Polypathological Patient versus Automated Detection by Means of Combined Identification through ICD-9-CM Codes
(MDPI, 2019-05-06)
It is unknown whether the digital application of automated ICD-9-CM codes recorded in the medical history are useful for a first screening in the detection of polypathological patients. In this study, the objective was to ...
Artículo
A variant in the MICA gene is associated with liver fbrosis progression in chronic hepatitis C through TGF-β1 dependent mechanisms
(Nature Research, 2019-02-05)
Hepatocarcinogenesis is tightly linked to liver fibrosis. Recently, two GWAS variants, MICA rs2596542 and DEPDC5 rs1012068 were identified as being associated with the development of HCV-induced hepatocellular carcinoma ...
Artículo
Long Daytime Napping Is Associated with Increased Adiposity and Type 2 Diabetes in an Elderly Population with Metabolic Syndrome
(MDPI, 2019-07-19)
Research examining associations between objectively measured napping time and type 2 diabetes (T2D) is lacking. This study aimed to evaluate daytime napping in relation to T2D and adiposity measures in elderly individuals ...
Artículo
High-resolution anoscopy in HIV-infected men: Assessment of the learning curve and factors that improve the performance
(Elsevier, 2019)
To determine the required learning time for high-resolution anoscopy (HRA)-guided biopsy to detect histological high-risk squamous intraepithelial lesions (hHSIL) and to identify factors that impact on the training pro ...
Artículo
Next generation sequencing of PD-L1 for predicting response to immune checkpoint inhibitors
(BMC, 2019)
Background PD-L1 immunohistochemistry (IHC) has been traditionally used for predicting clinical responses to immune checkpoint inhibitors (ICIs). However, there are at least 4 different assays and antibodies used for PD-L1 ...
Artículo
Impact of Sarcopenia and Frailty in a Multicenter Cohort of Polypathological Patients
(MDPI, 2019-04-18)
The prevalence, relationships and outcomes of sarcopenia and frailty in polypathological patients remain unknown. We performed a multicenter prospective observational study in six hospitals in order to assess prevalence, ...
Artículo
Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population at High Cardiovascular Risk
(MDPI, 2019-04-01)
The aim of the study was to evaluate sleep duration and sleep variability in relation to serum uric acid (SUA) concentrations and SUA to creatinine ratio. This is a cross-sectional analysis of baseline data from 1842 elderly ...
Artículo
New horizons in breast cancer: the promise of immunotherapy
(Springer, 2019)
Immunology and immunotherapy of cancer is an expanding feld in oncology, with recent great achievements obtained through the new successful approaches implemented to circumvent immune evasion, which is undoubtedly ...
Artículo
Analysis of the burden and variability in the management of NAFLD patients in the clinical practice: unifying the required criteria
(Sociedad Española de Patología Digestiva, 2019)
Aim: to assess the prevalence of non-alcoholic fatty liver disease (NAFLD) in the gastroenterology outpatient clinic and describe the use of the resources accordingly. Methods: a prospective and observational study of 403 ...