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Embracing monogenic Parkinson's disease: the MJFF global genetic PD cohort
(Wiley, 2023)
ABSTRACT: Background: As gene-targeted therapies are increasingly being developed for Parkinson’s disease (PD), identifying and characterizing carriers of specific genetic pathogenic variants is imperative. Only a ...
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Leadership, management, quality, and innovation in organ donation: 2019 Kunming recommendations for One Belt & One Road countries
(Wiley-Blackwell, 2021-08-24)
The findings and recommendations of the 2019 consensus conference in organ donation, held in Kunming, China, are here reported. The main objective of the conference was to gather relevant information from experts involved ...
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Targeting Hedgehog Signaling with Glasdegib in Patients with Refractory Sclerotic Chronic GVHD: A Report of Two Phase I/II Trials
(American Association for Cancer Research, 2023)
Purpose: Sclerotic chronic GVHD (scGVHD) is characterized by progressive skin fibrosis and frequent refractoriness to available therapies. Aberrant activation of Hedgehog signaling in dermal fibroblasts has been implicated ...
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104-week safety and effectiveness of dupilumab in the treatment of severe atopic dermatitis. The experience of 5 reference dermatology units in Spain
(Sociedade Brasileira de Dermatologia. Elsevier, 2021-11)
Atopic Dermatitis (AD) is a multifactorial disease resulting from the interaction of genetic predisposition, environmental triggers, disruption of skin barrier function, and type 2 immune dysregulation. Management of mild ...
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La fractura de cadera en Latinoamérica. ¿Se está aproximando a la experiencia europea de los últimos años?
(2018)
La fractura de cadera (FC) ya sea por fragilidad o por osteoporosis en ancianos con una media de 80 años, en pacientes con comorbilidad sin intervención tienen una mayor mortabilidad. Además, en los hombres ese aumento ...
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Microstructural and strength changes in trabecular bone in elderly patients with type 2 diabetes mellitus
(MPDI, 2021-03-23)
Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases worldwide and it is associated with an increased risk of osteoporosis and fragility fractures. Our aim is to analyze the effect of T2DM on bone ...
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Emerging pharmacological treatment options for MAFLD
(2022)
Metabolic dysfunction–associated fatty liver disease (MAFLD) prevalence and incidence is rising globally. It is associated with metabolic comorbidities, obesity, overweight, type 2 diabetes mellitus, and at least two ...
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Homocysteine levels, genetic background, and cognitive impairment in Parkinson’s disease
(Springer Nature, 2023)
Background: Hyperhomocysteinemia is considered an independent risk factor for cognitive impairment. Objective: To study the correlation between homocysteine levels and cognitive impairment in patients with PD. Methods: ...
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Clinical application of Magnetic resonance elastography in hepatocellular carcinoma: From diagnosis to prognosis
(Elsevier, 2023)
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a major public health problem worldwide. Liver fibrosis is closely correlated with liver functional reserve and the risk of HCC development. Meanwhile, ...